哈尔滨商业大学学报（自然科学版）2003，Vol.19Issue(2)：127-134,8.
TDI 哮喘的免疫病理学机制研究现状
Studies on immunopathogenesis of TDI-induced asthma
摘要
Abstract
Tolune diisocyanate(TDI), highly reactive chemicals used in the production of polyurethane, are currently the most reported cause of chemically induced occupational asthma. Summarizes the immunopathogenesis of the TDI- induced asthma. Knowledge of the target biomolecule of TDI, the sensitizing potency, the character of airway inflammatory reaction, and the cellular sites of reaction are fundamental to understanding TDI toxicity and disease. The TDI-induced humoral and cell immune response, the oxidative function in vitro, and the migration of dendritic cells will be described and their potential contributions to immunopathogenesis discussed. The changes of gene expression on TDI-induced asthma will be emphasized at last. It is anticipated that greater understanding of the immunopathogenesis of TDI-induced asthma, should contribute to useful marker of TDI exposure and clinically early disease of the occupational asthma.关键词
二异氰酸甲苯酯(TDI)/职业性哮喘/免疫病理学机制Key words
tolune diisocyanate(TDI)/occupational asthma/immunopathogenesis分类
医药卫生引用本文复制引用
季宇彬,刘春颖,于蕾,纪红蕊..TDI 哮喘的免疫病理学机制研究现状[J].哈尔滨商业大学学报（自然科学版）,2003,19(2):127-134,8.基金项目
国家自然科学基金资助项目(30271108). （30271108）
