首页|期刊导航|中华医学杂志（英文版）|Relationship among soluble CD105,hypersensitive C-reactive protein and coronary plaque morphology:an intravascular ultrasound study
Relationship among soluble CD105,hypersensitive C-reactive protein and coronary plaque morphology:an intravascular ultrasound study
CUI Song GE Chang-jiang LIU Hong L(U) Shu-zheng CHEN Yun-dai HE Guo-xiang MENG Li-jun LIU Jian-ping SONG Zhi-yuan LIU Xian-liang SONG Xian-tao
中华医学杂志（英文版）2008，Vol.121Issue(2)：128-132,5.
中华医学杂志（英文版）2008，Vol.121Issue(2)：128-132,5.
Relationship among soluble CD105,hypersensitive C-reactive protein and coronary plaque morphology:an intravascular ultrasound study
Relationship among soluble CD105,hypersensitive C-reactive protein and coronary plaque morphology:an intravascular ultrasound study
摘要
Abstract
Background Rupture of unstable plaque with subsequent thrombus formation is the common pathophysiological substrate of acute coronary syndrome(ACS).It is of potential significance to explore the blood indexes predicting plaque characteristics.We investigated the relationship among soluble CD105,hypersensitive C-reactive protein(hs-CRP),and coronary plaque morphology.Methods A clinical study from April 2004 to December 2006 was conducted in 130 patients who were divided into 3 groups:56 patients(43.1%)in stable angina(SA)group,52 patients(40.0%)in unstable angina(UA)group and 22 patients(16.9%)in acute myocardial infarction group.The concentrations of soluble CD105 and hs-CRP were measured ln all of the patients by cardioangiography(CAG).Plasma samples of arterial blood were collected prior to the procedure.The levels of soluble CD105 and hs-CRP were measured by enzyme-linked immunosorbent assay (ELISA).Results Unstable and ruptured plaque was found more frequently in patients with acute myocardial infarction and UA.External elastic membrane cross-sectional area(EEM CSA),plaque area,lipid pool area and plaque burden were significantly larger in the ruptured and unstable plaque group.Positive remodeling,thinner fabric-cap,smaller minimal lumen cross-sectional area(MLA),dissection and thrombus were significantly more frequent in the ruptured and unstable plaque group.Remodeling index(RI)was positively correlated with the levels of soluble CD105 in the UA group (r=0.628,P＜0.01)and the acute myocardial infarction group(r=0.639,P＜0.01).The Ievels of soluble CD105 and hs-CRP were higher in the ruptu red plaque group.Soluble CD105＞4.3 ng/ml was used to predict ruptured plaque with a receiver operating characteristic(ROC)curve area of 0.77(95%confidence interval(Cl),66.8%-87.2%),a sensitivity of 72.8%,a specificity of 78.0%and an accuracy of 70.2%(P＜0.01),similarly for hs-CRP＞5.0 mg/ml with a ROC curve area of 0.70 (95%Cl,59.2%-80.2%),a sensitivity of 70.2%,a specificity of 76.2%and an accuracy of 67.2%(P＜0.01).Conclusions The plaque characteristics correlate with the clinical presentation.The elevation of soluble CD105 and hs-CRP is related to the plaque instability and rupture.关键词
intravascular ultrasound,"soluble CD105/neovascularization/hypersensitive C-reactive proteinKey words
intravascular ultrasound,"soluble CD105/neovascularization/hypersensitive C-reactive protein分类
医药卫生引用本文复制引用
CUI Song,GE Chang-jiang,LIU Hong,L(U) Shu-zheng,CHEN Yun-dai,HE Guo-xiang,MENG Li-jun,LIU Jian-ping,SONG Zhi-yuan,LIU Xian-liang,SONG Xian-tao..Relationship among soluble CD105,hypersensitive C-reactive protein and coronary plaque morphology:an intravascular ultrasound study[J].中华医学杂志（英文版）,2008,121(2):128-132,5.基金项目
This study was supposed by a grant from Scientific Bureau of Beijing (No.D0906006040191). （No.D0906006040191）
