华西医科大学学报2001，Vol.32Issue(1)：129-130,139,3.
64例狼疮性肾炎大剂量环磷酰胺冲击治疗的研究
Study on Bolus Cyclosphamide Treament for 64 Cases of Lupus Nephritis
刘辉 1陈永涛 1左川 1谢其冰 1王忠明 1王玲 1林懋贤1
作者信息
摘要
Abstract
Objective To report on the dosing, efficacy and s ide-effects ofbolus cyclosphamide treatment for lupus nephritis (LN). Methods 64 consecuti ve cases of LN with 10 or more erythrocytes per high -power field, proteinuri a (>1g of protein per day ) and serum creatinine increased (>133μmol/L) were tre ated by bolus therapy with cyclophosphamide (CTX) given monthly for 6 months and then quarterly for 18 months. Results 49 patients had renal remission (defin ed as <10 erythrocytes per high-power field, absence of cellular casts, excreti o n of <1g of protein per day and normal serum creatinine). The mean of doses was 1.1g for each time (0.6-1.6g ), the mean of times of bolus CTX needed was 3.6 (1 -8 times). The adverse events were amenorrhea (in 41% female patients), herpes z oster (in 13% patients ) and hemorrhagic cystitis (in 1 patient). Conclu sion The results indicate that monthly bolus CTX therapy is effective and safe for patients with LN. Its adverse effect is relatively not a serious p roblem.关键词
狼疮肾炎/环磷酰胺冲击治疗/肾损害缓解引用本文复制引用
刘辉,陈永涛,左川,谢其冰,王忠明,王玲,林懋贤..64例狼疮性肾炎大剂量环磷酰胺冲击治疗的研究[J].华西医科大学学报,2001,32(1):129-130,139,3.
