中华医学杂志（英文版）Issue(9)：1299-1303,5.
Diffuse panbronchiolitis with histopathological confirmation among Chinese
Diffuse panbronchiolitis with histopathological confirmation among Chinese
谢广顺 1李龙芸 1刘鸿瑞 2张伟宏 3朱元珏1
作者信息
- 1. Department of Respiratory Medicine,Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
- 2. Department of Pathology,Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
- 3. Department of Radiology,Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
- 折叠
摘要
Abstract
Background Diffuse panbronchiolitis (DPB) was originally and is still primarily reported in Japan, rarely in other countries. As macrolide therapy is effective for this disease with once dismal prognosis, familiarity with its clinical features is urgently needed, especially for clinicians outside Japan. The objectives of this study were to investigate the clinical features of DPB in a Chinese population and propose diagnostic procedures that will lead to increased awareness of this treatable disease among clinicians, ultimately allowing for more rapid diagnosis.
Methods After a literature review, the clinical features of DPB were histopathologically confirmed in a series of 9 cases either by open lung biopsy or video-assisted thoracic surgical biopsy, resulting in the largest series of confirmed DPB cases in a non-Japanese population. Here, the cases are retrospectively described and diagnostic procedures are discussed.Conclusions Although its clinical features may vary with disease course and ethnic populations, most cases of DPB can be diagnosed or suggested according to clinical diagnostic criteria. However, underdiagnosis as a result of unfamiliarity with its clinical features and diagnostic criteria prevails. If difficulty in diagnosis arises, the diagnosis should be based on clinicopathological features and the exclusion of other diseases. Few cases can be confirmed by transbronchial biopsies; in these cases, either an open-lung biopsy or a video-assisted thoracic surgical lung biopsy should be recommended.关键词
diffuse panbronchiolitis/open lung biopsy/video-assisted thoracic surgical lung biopsyKey words
diffuse panbronchiolitis/open lung biopsy/video-assisted thoracic surgical lung biopsy分类
医药卫生引用本文复制引用
谢广顺,李龙芸,刘鸿瑞,张伟宏,朱元珏..Diffuse panbronchiolitis with histopathological confirmation among Chinese[J].中华医学杂志（英文版）,2004,(9):1299-1303,5.
