中国康复2001，Vol.16Issue(1)：1-3,3.
胆红素脑病仔兔脑组织单胺类神经递质含量变化的研究
The Changes of Monomine in the Rabbits with Bilirubin-induced Encephalopathy
摘要
Abstract
Objective To observe the changes of monomine in brain and tostudy the relationship between monomine and bilirubin neurotoxicity. Methods A model of bilirubin-induced encephalopathy was developed. The newborn rabbits at age of 2 to 5 days were subjected to the injection of bilirubin intraperineally and then sacrificed to determine the bilirubin concentration of serum and brain and monomine levels of brain tissue. Results The levels of dopamine (DA) and 5-HT were increased and NE decreased in the brain tissue of the rabbits with bilirubin-induced encephalopathy as compared with control group, but were not related with bilirubin concentration and time of exposure. Conclusion The changes in monomine in the brain tissue of the rabbits with bilirubin-induced encephalopathy were related to the bilirubin neurotoxicity.关键词
胆红素脑病/脑组织/单胺类神经递质/动物模型分类
医药卫生引用本文复制引用
文香淑,李晓捷,郭丽,李林,姜志梅..胆红素脑病仔兔脑组织单胺类神经递质含量变化的研究[J].中国康复,2001,16(1):1-3,3.基金项目
黑龙江省科学技术计划项目(G99 C22-4) （G99 C22-4）
