中国口腔种植学杂志2001，Vol.6Issue(1)：1-3,30,4.
胶原膜与骨形成蛋白复合物的成骨作用研究
Osteoinductive Potential of Collagen Membrane Incorporated with BMP in Skull Defects of Rats
陈钢 1赵士杰 2俞光岩 2王会信3
作者信息
- 1. 深圳市中心医院口腔科 518036
- 2. 北京大学口腔医学院颌面外科
- 3. 军事医学科学院基础医学研究所
- 折叠
摘要
Abstract
To study the function of BMP incorporated membrane (BIM) in repairing skull trephined defeets in rats. Methods: Biodegradable GTR membrane with an osteoinductive potential was prepared by incoiporating rhBMP-2 in collagen membrane(BIM). Three 5mm trephined defects were produced in the skull of each rat. The defects were treated according to four different alternative ways: (1) covered by BIM on the dura and the perierania biBIM defect; (2) covered by BIM only on the pericrania ( unilateral BIM defect); (3) covered by collagen membrane on the pericrania (membrane defect); (4) filled with autogenous blood only as contral.The defect sites were studied radiographically and histologically in 2, 4 and 6 weeks after operation. Results: A quantitative radiographic analysis showed significantly more bone bridging area in BIM defects than that in membrane defects and control defects (P ＜ 0.01). And there was significantly more bone bridging area in biBIM defect than that in unilateral BIM defects in 4 and 6 weeks groups (P ＜ 0.05). 6 weeks after operation, the defects covered by BIM bilaterally were filled by bone completely. Histological and fluorescent evaluation showed bone regeneration pattern of BIM defects was multicentric and not merely centripetal ingrowth from defect rim. Conclusion: BMP-incorporated membrane(BIM) was an ideal GTR membrane to have mechanical barrier and have potential osteoinduction.关键词
骨缺损/组织引导再生膜/骨形成蛋白Key words
bone morphogenetic protein/bone defects/guided bone regeneration分类
医药卫生引用本文复制引用
陈钢,赵士杰,俞光岩,王会信..胶原膜与骨形成蛋白复合物的成骨作用研究[J].中国口腔种植学杂志,2001,6(1):1-3,30,4.
