中国普通外科杂志2001，Vol.10Issue(2)：130-133,4.
血管内皮生长因子在原发性肝细胞癌中的表达及其作用
The expression and clinical significance of vascular endothelial growth factor in primary hepatocellular carcinoma
周天保 1杨爱国 1盛茂鑫 2付华群2
作者信息
- 1. 解放军第一七五医院普外科,
- 2. 江西医学院第二附属医院普外科,
- 折叠
摘要
Abstract
Objective To study the relationship between the expression of vascular endothelial growth factor (VEGF) and invasion, metastasis of primary hepatocellular carcinoma (PHCC). Methods Paraffin-embedded specimens from 30 patients with PHCC undergoing radical resection were studied. Agiogenesis was assessed by the expression of VEGF and microvascular density (MVD) using LSAB immunohistochemical staining. Results (1) The level of VEGF and MVD in PHCC was higher than that in the paratumorous tissue (P<0.05). (2) The level of VEGF expression and MVD in PHCC with tumor metastasis or in nonencapsulated tumors were higher than that in PHCC without metastasis or in well encapsulated tumors (P<0.05). (3) There was no significant differance in the expression of VEGF and MVD between large PHCC (diameter >5cm) and small ones (diameter ≤5cm). (4) The expression of VEGF was positively correlated with MVD (P<0.01). Conclusions The expression of VEGF and MVD are highly correlated with invasion and metastasis in PHCC, may serve as a parameter for determining tumor metastasis and prognosis which may suggest a new idea to supervise and treat PHCC.关键词
肝肿瘤/病理学/癌,肝细胞/病理学/肿瘤转移/肝肿瘤/血液供给/血管内皮生长因子分类
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周天保,杨爱国,盛茂鑫,付华群..血管内皮生长因子在原发性肝细胞癌中的表达及其作用[J].中国普通外科杂志,2001,10(2):130-133,4.
