中国病理生理杂志2000，Vol.16Issue(12)：1304-1306,3.
小柴胡汤对糖皮质激素受体及其mRNA的调节作用
Regulation of glucocorticoid receptor and its mRNA by Tsiao Shihutang
杨霞 1王浩丹2
作者信息
- 1. 山东医科大学附属医院核医学科，山东济南 2500012
- 2. 山东医科大学同位素中心实验室，山东济南 2500012
- 折叠
摘要
Abstract
AIM: In order to explore the mechanism of the GC - like effect of Tsiao Shaihutang (TSS), the down - regulation of glucocorticoid receptor and mRNA by TSS were studied. METHODS: GR sites were determined by receptor radio ligand binding assay method. At the same time, GR mRNA level was determined by quantitative reverse- transcriptive polymerase chain reaction (RT- PCR) method. RESULTS: (1) GR sites and GR mRNA level were down - regulated significantly after GC, TSS (P < 0.01 ) treatment . (2) GR sites and GR mRNA level in GC plus TSS group were obviously higher than those in GC group (P < 0.01 ). CONCLUSIONS: These data suggested that TSS can significantly down- regulate GR and GR mRNA level.关键词
中草药/受体,糖皮质激素/RNA,信使/基因表达Key words
Drugs, chinese herbal/Receptors, glucocorticoid/RNA, messenger/Gene expression分类
医药卫生引用本文复制引用
杨霞,王浩丹..小柴胡汤对糖皮质激素受体及其mRNA的调节作用[J].中国病理生理杂志,2000,16(12):1304-1306,3.
