首页|期刊导航|中华医学杂志（英文版）|Prevalence of antimicrobial resistance of Streptococcus pneumoniae in Chinese children: four hospitals surveillance
中华医学杂志（英文版）2003，Vol.116Issue(9)：1304-1307,4.
Prevalence of antimicrobial resistance of Streptococcus pneumoniae in Chinese children: four hospitals surveillance
Prevalence of antimicrobial resistance of Streptococcus pneumoniae in Chinese children: four hospitals surveillance
摘要
Abstract
Objective To investigate the nasal carriage of antibiotic-resistant pneumococci in children of <5 years old in the following four cities, Beijing, Shanghai, Guangzhou and Xi'an.Methods A total of 647 pneumococci strains were isolated and detected. Minimal inhibition concentrations (MICs) of antibiotics were determined by E-test. Disk diffusion test was used for the measurement of antimicrobial susceptibility.Results Prevalence of penicillin non-susceptible Streptococcus pneumoniae in the four cities was 41%, with Guangzhou (60.8%) ranking first, followed by Xi'an (45%), Shanghai (37%) and Beijing (25.9%). The majority of penicillin non-susceptibility isolates (23.9%-53.8%) had a low level of resistance (MIC 0.64-1.5 μg/ml). The most sensitive antimicrobials in terms of percentage of susceptible organisms were amoxicillin-clavulanic acid (99.4%), followed by ceftriaxone (92.1%); cefurxime and cefaclor were slightly more sensitive than penicillin with susceptibility of 74.8% and 77.9%. Erythromycin, tetracycline and TMP-SMZ were highly resistant (83.6%, 82.1% and 76.2% respectively). Among erythromycin resistant isolates, 100% were resistant to azithromycin, 98.6% to clarithromycin, 97.2% to roxithromycin and spiramycin, and 96.6% to clindamycin. 97.2% (141/145) were typical of the macrolides-lincosamides-streptogramons B (MLSB ) resistance phenotype, and 2.8% (4/145) were M phenotype. The group of PRSP was with significantly higher rates of non-susceptibility for ceftriaxone (18.4%), cefurxime (58.6%), cefaclor (53.4%), compared with the group of PEN-S (0.5%, 1.8% and 0.2%, respectively) and the rate of multi-drug resistance in the isolates of PRSP group (92.9%) was significantly higher than that of PEN-S group (59.2%).Conclusion The rates of penicillin and multi-drug resistance among isolates of pneumococci carried nasally in are high children and the high prevalence of multi-drug resistance in the Chinese population may be becoming one of the most serious problems in this century.关键词
Streptococcus pneumoniae/penicillin non-susceptibility/multi-drug resistanceKey words
Streptococcus pneumoniae/penicillin non-susceptibility/multi-drug resistance分类
医药卫生引用本文复制引用
沈叙庄,陆权,叶启慈,张国成,俞桑洁,张泓,邓秋莲,杨永弘..Prevalence of antimicrobial resistance of Streptococcus pneumoniae in Chinese children: four hospitals surveillance[J].中华医学杂志（英文版）,2003,116(9):1304-1307,4.基金项目
This study was supported by a grant from the National Natural Science Foundation of China (No. 30007093). （No. 30007093）
