中国病理生理杂志2000，Vol.16Issue(12)：1307-1309,3.
神经肽Y对bcl-2，bax，fas基因表达和血管平滑肌细胞增殖的作用
Effect of neuropeptide Y on bcl- 2, bax, fas expressions and proliferation in vascular smooth muscl cells
摘要
Abstract
AIM: To explore the effect of neuropeptide Y on expression of apoptosis associated genes and proliferation in vascular smooth muscle cells(VSMC). METHODS: The proliferation activity of VSMC was dterminded by MTr colorimetry. The average fluorescence intensity that represented VSMC nuclear antigen (PCNA) and bcl -2, bax, fas expressions was quantitatively measured by fluorescence immunohistoehemistry. RESULTS: Compared with control, the expressions of bcl - 2, bax, fas, PCNA and the VSMC proliferation activity in VSMC treated with NPY were significantly increased. CONCLUSION: NPY may increase the expression of apoptosis associated genes in VMSC and promote its proliferation.关键词
细胞/凋亡/神经肽Y/肌,平滑,血管Key words
Cells/Apoptosis/Neuropeptide Y/Muscle, smooth, vascular分类
生物科学引用本文复制引用
高聪,陈敏生,黄少华,刘健康..神经肽Y对bcl-2，bax，fas基因表达和血管平滑肌细胞增殖的作用[J].中国病理生理杂志,2000,16(12):1307-1309,3.基金项目
广东省自然科学基金资助(No.980466) （No.980466）
