中华医学杂志（英文版）2002，Vol.115Issue(9)：1308-1311,4.
GYS1和β3-AR基因与2型糖尿病餐后高血糖和血尿酸的关系
Association of GYS1 and β3-AR gene with postprandial hyperglycemia and serum uric acid in type 2 diabetes mellitus
王国英 1李琼芳 1牛天华 2陈常中 2徐希平2
作者信息
- 1. 北京大学第三医院内分泌科,北京,100083
- 2. The Program of Population Genetics, Harvard School of Public Health, Boston, MA 02115-6096, USA
- 折叠
摘要
Abstract
Objective To determine the relationships of Met416Val and XbaI polymorphism of muscle glycogen synthase (GYS1) gene and Trg64Arg variant of the β3-adrenergic-receptor (β3-AR) gene with type 2 diabetes mellitus (DM) and its intermediate phenotypes in the Chinese population. Methods Polymerase chain reaction-oligonucleotide ligation assay and restriction fragment length polymorphism assay were used to evaluate the GYS1 and β3-AR gene polymorphisms in 102 pairs of case-control Chinese spouses. Results Subjects with Met416Val variant had a significantly higher 2-hour post-glucose level than subjects without this variant had in diabetic group (P=0.032). The Met416Val polymorphism of GYS1 gene was not significantly associated with the risk of type 2 DM (adjusted OR=1.67; 95% CI: 0.73-3.81, P=0.223). Subjects with Trp64Arg variant had a significantly higher serum uric acid level than subjects without this variant had in diabetic group (P=0.034). The combination of BMI and Arg64 allele carrier of the β3-AR gene increased the diabetic risk over four-fold (adjusted OR=4.00; 95%CI: 1.53-10.45, P=0.005). Conclusions In the Chinese population, Met416Val polymorphism is identified in a subgroup of diabetic subjects with high 2-hour post-glucose. It will explain why some diabetic patients appear to be genetically predisposed to developing high postpradial glucose level. The presence of the Arg64 allele in the β3-AR gene may predispose patients to higher serum uric acid level.关键词
肌肉糖元合酶基因/β3肾上腺素能受体基因/2型糖尿病/餐后血糖/血尿酸Key words
muscle glycogen synthase gene/β3-adrenergic-receptor gene/type 2 diabetes mellitus/postprandial glucose/serum uric acid分类
医药卫生引用本文复制引用
王国英,李琼芳,牛天华,陈常中,徐希平..GYS1和β3-AR基因与2型糖尿病餐后高血糖和血尿酸的关系[J].中华医学杂志（英文版）,2002,115(9):1308-1311,4.
