中国病理生理杂志2000，Vol.16Issue(12)：1310-1312,3.
急性淋巴细胞白血病细胞β2整合素及L-选择素的表达与意义
The expression of β2 integrins and L - selectin on acutelymophocytic leukemic cells and its clinical implications
摘要
Abstract
AIM and METHODS: To investigate the expression of adhesion molecule β2 integrins (CD11a、 CD11b) and L-selectin(CD62L )on Acute Lymophocyte Leukemia(ALL) cells and its Clinical Implications. Adhesion molecules CD11a、CD11b、 CD62L of 45 ALL patients and 25 health people were measured by flow - cytometric analysis. RESULTS :①CD11a and CD11b expression were lower on ALL cells than the normal hematopoietic cells. The rate of low expression was 100% for CD11b, 50% for CD11a,respectively. CD62L expression were higher on ALL cells than the normal hematopoietic cells.②The CD11a was lower expressed on B - ALL than T- ALL. CD62L was higher on T- ALL than B- ALL. ③The expression of CD11a in the invasion group was much higher than that in the non - invasive group( P < 0.05).④The levels of CD11a,CD11b were returned to normal levels at remission. CONCLUSION: These results suggest that there are abnormalities in the expression of cell adhesion molecules in ALL which may help identify ALL subtypes and the treatment effect.关键词
白血病,淋巴细胞,急性/细胞粘着分子/流式细胞术Key words
Leukemia, lymphocytic, acute/Cell adhesion molecules/Flow cytometry分类
医药卫生引用本文复制引用
童秀珍,陈运贤,洪文德,罗绍凯,彭爱华..急性淋巴细胞白血病细胞β2整合素及L-选择素的表达与意义[J].中国病理生理杂志,2000,16(12):1310-1312,3.基金项目
广东省卫生厅基金资助(No．19994) （No．19994）
