中华医学杂志（英文版）2003，Vol.116Issue(9)：1312-1317,6.
Clinical and histological characteristics of chronic hepatitis B with negative hepatitis B e-antigen
Clinical and histological characteristics of chronic hepatitis B with negative hepatitis B e-antigen
彭劼 1骆抗先 1朱幼芙 1郭亚兵 1章廉 1侯金林1
作者信息
- 1. Department of Infectious Diseases, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
- 折叠
摘要
Abstract
Abstract:Objective To study the clinical and histological features of chronic hepatitis B (CHB) with negative hepatitis B e-antigen (HBeAg). Methods A tatal of 743 in-patients with chronic hepatitis B were recruited into the study and divided into two groups according to the HBeAg status. The correlation among alanine transaminase (ALT) levels, hepatitis B virus (HBV) DNA semiquantification, and the liver histopathological data were dectected.Results Of the 743 successive in-patients, 267 (35.9%) were HBeAg-negative. The HBDAG-negative group had significantly lower serologic HBV DNA levels (63.0% of<100 pg/ml) vs HBeAg-positive (42.6%, P<0.001), while more sever inflammation (58.1% of inflammatory scores of histological activeity index (HAIinf≥9) vs HBeAg-positive group (46.0%, P<0.001) and severe fibrosis (45.3% of fibrosis scores of histological activity index (HAIfib≥3) vs HBeAg-positive group (27.9%, P<0.001) of liver histology. In HBeAg-positive patients, increasing ALI levels were significantly associated with high inflammation and fiborsis scores and low HBV DNA levels. However, it was not the case in the HBeAg-negative cases. In HBeAg-positive patients, 91.3% of them had HAIinf≥9 and 65.7% had HAIfib≥3 with HBV DNA>100 pg/ml, while 8.2% of them had HAIinf≥9 and 12.3% had HAIfib≥3 with HBV DNA<20 pg/ml, indicating an obverse correlation between HBV DNA levels and histology scores.Conclusions As regards clinical and histological background, the chronic HBeAg-negative hepatitis B is a different subpopulation from the HBeAg-positive counterpart.关键词
chronic hepatitis B/hepatitis B e-antigen/liver histologyKey words
chronic hepatitis B/hepatitis B e-antigen/liver histology分类
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彭劼,骆抗先,朱幼芙,郭亚兵,章廉,侯金林..Clinical and histological characteristics of chronic hepatitis B with negative hepatitis B e-antigen[J].中华医学杂志（英文版）,2003,116(9):1312-1317,6.
