中国现代医学杂志2001，Vol.11Issue(4)：13-14，17,3.
粘附分子ICAM-1、VCAM-1的表达与
肝细胞癌侵袭性的相关研究
EXPRESSION OF ICAM- 1 AND VCAM- 1 INHEPATOOCELLULAR CARCINOMA AND CORRELATION WITH INVASIVENESS
周文波 1戴宗晴 1袁房均 1于昌松2
作者信息
- 1. 东风汽车公司总医院外科
- 2. 同济医科大学附属同济医院外科
- 折叠
摘要
Abstract
Objective:To investigate the expression of ICAM- 1 and VCAM- 1 in hepatocellular carcinoma and correlation with invasiveness. Methods:The expression of ICAM- 1 and VCAM- 1 In 5 normal liver tissues、5 cases of cavernous hemangioma and 36 cases of HCC was investigated using immunohistochemical staining, which was performed on formalin- fixed and paraffin- embeded material. Results:ICAM- 1 and VCAM- 1 have no expression in normal liver tissues. The aberrant expression of ICAM- 1 was found in 25 cases ( 69.49% ) of HCC and VCAM- 1 was found in 23 cases (63.9%). Invasive HCC expressed high ICAM - 1 and VCAM- 1 than non- invasive ones (85. 7% vs 46.7% ;80.9% vs 40.0% ). The difference was significant (P< 0.05). Conclusions: ICAM- 1 and VCAM- 1 are related with malignant transformation and invasiveness of HCC. High expression of ICAM- 1 and VCAM- 1 is more frequently seen in high invasive HCC and was one of factors for development of its highly invasive potentials.关键词
癌,肝细胞细胞间粘附分子-1血管细胞粘附分子-1肿瘤侵袭性分类
医药卫生引用本文复制引用
周文波,戴宗晴,袁房均,于昌松..粘附分子ICAM-1、VCAM-1的表达与
肝细胞癌侵袭性的相关研究[J].中国现代医学杂志,2001,11(4):13-14，17,3.
