中国现代医学杂志2008，Vol.18Issue(1)：13-16,24,5.
小鼠日本血吸虫病肝纤维化肝脏CTGF的表达及意义
Expression and significance of connective tissue growth factor in murine schistosomiasis liver fibrosis
摘要
Abstract
[Objective] To study the expression and significance of connective tissue growth factor (CTGF) in murine schistosomiasis liver fibrosis. [Method] The mice infected with schistosoma japonicum were randomly divided into the model groups and the therapeutic groups. The hepatic expression of CTGF mRNA and protein was detected by reverse transcriptase polymerase chain reaction and immunohistochemical method respectively. Histological changes were observed by HE staining. The α-SMA positive cells were observed by immunohistochemical method.[Result] The expression of CTGF mRNA and protein and α-SMA positive cells in the model groups peaked at 10th week and then declined; there were significant differences at 10th, 14th, 16th week between the model groups and the therapeutic groups at the same period respectively; the expression of α-SMA+ positive cells had the same tendency as CTGF mRNA and protein. [Conclusion] The hepatic expression of CTGF is correlated to the murine schistosomiasis liver fibrosis; CTGF may take its biological effects by its action on HSCs.关键词
血吸虫病/肝纤维化/结缔组织生长因子/α-平滑肌肌动蛋白Key words
schistosomiasis/liver fibrosis/connective tissue growth factor/α-smooth muscle actin分类
医药卫生引用本文复制引用
余治健,向选东,蔡胜蓝,谭德明,李萍..小鼠日本血吸虫病肝纤维化肝脏CTGF的表达及意义[J].中国现代医学杂志,2008,18(1):13-16,24,5.基金项目
This work was supported by the research foundation from Hunan Bureau of Science and Technology. No.(2005)05SK3080 （2005）
