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头孢菌素C发酵液膜过滤的评价指标及其控制

王龙耀 王岚 鲁新宇

化工进展2009,Vol.28Issue(8):1319-1322,1342,5.
化工进展2009,Vol.28Issue(8):1319-1322,1342,5.

头孢菌素C发酵液膜过滤的评价指标及其控制

Performance evaluation and process control for the separation of CPC fermentation broth by membrane filtration

王龙耀 1王岚 1鲁新宇1

作者信息

  • 1. 江苏工业学院江苏省精细石油化工重点实验室,江苏,常州,213016
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摘要

Abstract

The clarification of fermentation broth is the first link in CPC separation and purification, which has a great influence on the quality, cost and production progress of the CPC product. The present paper provides several indexes for both of the membrane filtration process evaluation and the filtrate quality assessment in the filtration process of CPC fermentation broth. Parameters influencing the evaluation indexes are discussed with a mathematic model and quantitative models have been established, thus provides a rational route for filtrate quality control and production process optimization.

关键词

头孢菌素C/发酵液/膜过滤/质量评价

Key words

Cephalosporin C/fermentation broth/membrane filtration/quality control

分类

医药卫生

引用本文复制引用

王龙耀,王岚,鲁新宇..头孢菌素C发酵液膜过滤的评价指标及其控制[J].化工进展,2009,28(8):1319-1322,1342,5.

基金项目

江苏省精细石油化工重点实验室开放课题(KF0704)及校管科技开发项目(ZMF07020027). (KF0704)

化工进展

OA北大核心CSCDCSTPCD

1000-6613

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