中国当代儿科杂志2001，Vol.3Issue(2)：132-135,4.
儿童激素敏感性肾病综合征
CD30+细胞及TH2类细胞因子研究
State of CD30+ cells and TH2 cytokines in children with the steroid sensitive nephrotic syndrome
李永柏 1王莉佳 1肖玲莉 2李秋 1刘恩梅 1杨锡强1
作者信息
- 1. 重庆医科大学附属儿童医院内科,
- 2. 重庆渝北区人民医院儿科,
- 折叠
摘要
Abstract
Objective To study the TH2 state as represented by the percentage of CD30+ cells, levels of IL4, IL5, and IL6 in PBMC, and serum IgE levels in children with the steroid sensitive nephrotic syndrome (SSNS).Methods CD30+ cells were assayed using FACS. IL4, 5, 6 and serum IgE were determined using ELISA.Results There was a higher percentage of CD30+ cells (11.96%) and higher levels of IL4 (lg 2.11 pg/ml) and serum IgE (299 IU/ml) in children with SSNS compared to the healthy control group (2.81%, lg 1.37 pg/ml, 110 IU/ml, respectively) (P<0.01). No significant difference was found in the levels of IL5 and IL6 in the two groups. There was a significant correlation between the percentage of CD30+ cells and IL4 (r=0.94, P<0.01) and between CD30+ cells and serum IgE (r=0.74, P<0.01). NO correlation was noted with IL5 (r=-0.39, P>0.05) or with IL6 levels (r=0.08, P>0.05).Conclusions The abnormal increase of CD30+ cells does not mean that all TH2 cells are activated. The TH1/TH2 imbalance in children with SSNS is not proved in this study.关键词
肾病综合征/CD30细胞/白细胞介素/IgE/儿童分类
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李永柏,王莉佳,肖玲莉,李秋,刘恩梅,杨锡强..儿童激素敏感性肾病综合征
CD30+细胞及TH2类细胞因子研究[J].中国当代儿科杂志,2001,3(2):132-135,4.
