物理化学学报2009，Vol.25Issue(7)：1327-1331,5.
耦合生物细胞体系中内噪声对检测弱刺激的积极作用
Constructive Role of Internal Noise for the Detection of Weak Stimulation in a Coupled Biological Cell System
摘要
Abstract
By constructing a mesoscopic stochastic model for intracellular calcium oscillations in coupled cell system,we investigated the influence of internal noise on the detection of weak stimulation using the chemical Langevin equation(CLE).We found that an optimal cell size V existed for ac oupled cell chain length N and an optimal value of N existed for a given cell size V,At these values,the collective calcium oscillations showed the best performance,indicating the occurrence of"system size resonance(SSR)"or"internal noise stochastic resonance(INSR)".And such a phenomenon Was robust to the coupling strength.Living cells may have learned to exploit the internal noise to detect weak stimulation via the mechanism of INSR,and then encode information to specifically regulate distinct cellular functions.It is interesting to note that the optimal cell size is always present at V≈103 μm3,which is close to the real living cell size in vivo.Since the internal noise in living systems can not be ignored and the systems may often encounter weak stimulations,our findings might have significance for stimulation detecting processes in living systems.关键词
钙振荡/内噪声/化学Langevin方程/刺激检测Key words
Calcium oscillation/Internal noise/Chemical Langevin equation/Stimulation detection分类
化学化工引用本文复制引用
李红英,毕建洪,马娟..耦合生物细胞体系中内噪声对检测弱刺激的积极作用[J].物理化学学报,2009,25(7):1327-1331,5.基金项目
安徽商校省级自然科学基金(KJ2009B066Z)及国家自然科学基金(20871039,20673106)资助项目The project was supported by the Natural Science Foundation of Higher Education of Anhui Province,China(KJ2009B066Z)and National Natural Science Foundation of China(20871039,20673106) （KJ2009B066Z）
