中华临床免疫和变态反应杂志2009，Vol.3Issue(2)：133-138,6.
调节性T细胞与系统性红斑狼疮
T-regulatory Cells and Systemic Lupus Erythematosus
杨华夏 1张烜 1张文 1张奉春 1唐福林1
作者信息
- 1. 中国医学科学院,北京协和医学院,北京协和医院风湿免疫科,北京,100032
- 折叠
摘要
Abstract
Thymus-derived CD4+CD25+ T-regulatory cells (Tregs) play an important role in the mechanisms of peripheral immune tolerance. CD25 molecule at high level of expression is the most widely employed marker of Tregs. Foxp3 is currently the most specific marker for CD4+ Tregs. Seeking for proper cell surface markers would be the crucial step for further investigation of Tregs. Recent studies have shown a significant defect in Treg cell number and/or function in active systemic lupus erythematosus (SLE), which may provide new ways for the treatment of this devastating disorder.关键词
系统性红斑狼疮/调节性T细胞Key words
systemic lupus erythematosus/T regulatory cells分类
医药卫生引用本文复制引用
杨华夏,张烜,张文,张奉春,唐福林..调节性T细胞与系统性红斑狼疮[J].中华临床免疫和变态反应杂志,2009,3(2):133-138,6.
