中华医学杂志（英文版）2004，Vol.117Issue(1)：133-139,7.
The role of inflammatory stress in acute coronary syndrome
The role of inflammatory stress in acute coronary syndrome
摘要
Abstract
Objective To summarize current understanding of the roles of anti-inflammatory and proinflammatory mechanisms in the development of atherosclerosis and acute coronary syndrome and to postulate the novel concept of inflammation stress as the most important factor triggering acute coronary syndrome. Moreover, markers of inflammation stress and ways to block involved pathways are elucidated.Data sources A literature search (MEDLINE 1997 to 2002) was performed using the key words "inflammation and cardiovascular disease". Relevant book chapters were also reviewed.Study selection Well-controlled, prospective landmark studies and review articles on inflammation and acute coronary syndrome were selected.Data extraction Data and conclusions from the selected articles providing solid evidence to elucidate the mechanisms of inflammation and acute coronary syndrome were extracted and interpreted in the light of our own clinical and basic research.Data synthesis Inflammation is closely linked to atherosclerosis and acute coronary syndrome. Chronic and long-lasting inflammation stress, present both systemically or in the vascular walls, can trigger acute coronary syndrome.Conclusions Inflammation stress plays an important role in the process of acute coronary syndrome. Drugs which can modulate the balance of pro- and anti-inflammatory processes and attenuate inflammation stress, such as angiotensin-converting enzyme (ACE) inhibitors/angiotensin Ⅱ receptor blockers, statins, and cytokine antagonists may play active roles in the prevention and treatment of acute coronary syndrome when used in addition to conventional therapies (glycoprotein Ⅱb/Ⅲa receptor antagonists, mechanical intervention strategies, etc).关键词
inflammation/acute coronary syndrome/atherosclerosisKey words
inflammation/acute coronary syndrome/atherosclerosis分类
医药卫生引用本文复制引用
沈成兴,陈灏珠,葛均波..The role of inflammatory stress in acute coronary syndrome[J].中华医学杂志（英文版）,2004,117(1):133-139,7.基金项目
This work was partly supported by the National Key Research Fund (G200005963). （G200005963）
