河南医科大学学报2001，Vol.36Issue(2)：134-136,3.
宫颈鳞癌组织中细胞凋亡的表达与临床生物学行为的关系
Relationship between apoptosis and clinical biological behavior of squamous cervical carcinoma
摘要
Abstract
Aim：To analysis the relationship between apoptosis and the clinical biological behavior of squamous cervical carcinoma．Methods： The apoptotic labeling indices(A-LI) and PCNA(proliferating cell nuclear antigen)-LI， were observed in 15 cases of normel cervical epithelia, 22 cases of CINⅠ/Ⅱ,16 cases of CINⅢ and 52 cases of ISCC (invasive squamous cervical carcinoma) tissues by using DNA nick end labeling technique and immunohistochemical staining.Results：No apoptotic cell was detected in normal cervical epithelium, A-LI increased with CINⅠ/Ⅱ→CINⅢ(P<0.05), A-LI in ISCC were significantly lower than those in CIN(P<0.01).PCNA-LI gradually increased with the development of every lesion grade of cervical carcinomas (P<0.05). A-LI decreased with the clinical stage and the differentiation degree progression, and were lower in pelvic lymphatic metastasis group than that without lymphatic metastasis. Conclusion: Apoptosis may play a negative regulating action by inhibiting excessive proliferation of cell during the developing course of squamous cervical carcinoma, and this regulating was inordinate in ISCC, Apoptosis is correlated to clinical biological behavior. The detection of apoptosis could contribute to evaluate the progress and prognosis of squamous cervical carcinoma.关键词
宫颈鳞癌/细胞凋亡/预后分类
医药卫生引用本文复制引用
吴丹,乔玉环,史惠蓉,李爱军,孙莹璞,张梦真..宫颈鳞癌组织中细胞凋亡的表达与临床生物学行为的关系[J].河南医科大学学报,2001,36(2):134-136,3.基金项目
河南省科技攻关项目 991170217 （）
