摘要
Abstract
BACKGROUND: Cognitive dysfunction brings difficulty for the rehabilitation treatment of patients with severe craniocerebral injury, and improving their cognitive function is the important task in clinical rehabilitative practice.OBJECTIVE: To observe the therapeutic effect of functional training in combination with almitrine-raubasine compound treatment for improving the cognitive function of patients with severe craniocerebral injury during recovery.DESIGN: Non-randomized concomitant controlled observation.SETTING: Department of Rehabilitation, Nanfang Hospital of Nanfang Medical University.PARTICIPANTS: Totally 48 patients with severe craniocerebral injury in recovery stage were admitted in Nanfang Hospital of Nanfang Medical University (coma time ≥ 6 hours after injury with Glasgow coma scores ≤ 8)between February and May 2000 and divided into Duxil (commercial name for almitrine-raubasine compound) group and conventional treatment group according to the willingness of the family members, with 24 cases in each group.METHODS: Patients in the conventional treatment group received treatment for neurotrophic support, improving blood circulation, correcting dehydration, and preventing and treating complications in addition to rehabilitative functional training that mainly consisted of motor function and performance training. On the basis of the above treatments, the patients in Duxil group were given additional Duxil, 1 tablet a time and twice a day,for an observation course of 1 month.tomography (SPECT) was performed before and after treatment to identify mental state examination (MMSE) was carried out before and after treatment to assess the patients' cognition function (totally 30 scores with orientation ability and memory of 15 scores respectively, higher grades suggests better cognitive function).RESULTS: According to intention-to-treat analysis, 48 cases all entered the result analysis. The number of ischemic foci was obviously reduced after treatment in both Duxil group and conventional treatment group, but the number was comparable between the two groups (2.00±0.68 vs 2.20±0.85).After treatment, the MMSE total scores showed no statistical difference between the two groups (P ＞ 0.05), but the scores for orientation and memory abilities increased remarkably after treatment, with the scores of Duxil group significantly higher than that of the conventional group (8.70±2.23 vs 5.60±1.77, P ＜ 0.05).CONCLUSION: Duxil can improve the cognitive function of patients with severe craniocerebral injury, with especially obvious effect on orientation and memory abilities.关键词
颅脑损伤/康复/阿米三嗪/认知/体层摄影术,发射型计算机,单光子分类
医药卫生
