中国现代医学杂志2007，Vol.17Issue(2)：134-137,4.
β-catenin与cyclinD1在胆道肿瘤中的表达及临床意义
Expression of β-catenin and cyclinD1 in Biliary tumors and its clinical significance
摘要
Abstract
[Objective] To investigate expression of β-catenin and cyclinD1 and its possible role in the tumors' development and progression. [Methods] Expression of β-catenin and cyclinD1 was immunohistochemically studied in gallbladder carcinoma (33 cases), and cholangiocarcinoma (35 cases), respectively. The results were analyzed with clinical-pathological data. [Results] Normal expression of β-catenin and cyclinD1 was found in 10 cases of normal biliary control samples. Abnormal expression of β-catenin and cyclinD1 overexpression was detected in 48.5% (16/33) and 54.5% (18/33) in samples of gallbladder carcinoma respectively. Similarly, abnormal expression of β-catenin and cyclinD1 overexpression were also found in cholangiocarcinoma, 51.4% (18/35) and 45.7% (16/35) respectively.Abnormal expression of β-catenin and cyclinD1 overexpression were related to TNM stages and/or tumor differentiation in these biliary tumors. Furthermore, in both gallbladder carcinoma and cholangiocarcinoma, abnormal β-catenin expression was correlated with cyclinD1 overexpression (P ＜0.05). [ Conclusion] Abnormal expression of β-catenin and cyclinD1 overexpression exist in biliary tumors. Correlation between abnormal expression of β-catenin and cyclinD1 overexpression suggests that WNT/β-catenin signaling pathway plays a role in biliary tumors' development and progression.关键词
胆囊癌/胆管癌/β-连环素/细胞周期素D1/Wnt信号传导通路Key words
carcinoma of gallbladder/cholangiocarcinoma/β-catenin/cyclin D1/Wnt signaling passway分类
医药卫生引用本文复制引用
乔岐禄,温泉,赵建勋,刘玉村..β-catenin与cyclinD1在胆道肿瘤中的表达及临床意义[J].中国现代医学杂志,2007,17(2):134-137,4.基金项目
Supported by the Project Spinsored by the Scientific Research Foundation for the Returned Ouerseas Chinese, State Education Ministry. （）
