中国临床康复2003，Vol.7Issue(1)：135-135,1.
脑源性神经营养因子抗体对大脑中动脉阻塞大鼠缺血损伤的影响
Effect of the antibody of brain-derived neurotrophic factor on the rat with ischemic injury from obstruction of middle cerebral artery
陈英辉 1王根发 1陈兴华 1姚革 1陈伟 1周永炜1
作者信息
- 1. Department of Neurology,Affiliated Xinhua Hospital of Second Medical University in Shanghai, Shanghai 200092,China
- 折叠
摘要
Abstract
AIM:To observe the effect of the antibody of brain derived neurotrophic factor(BDNF) by cortical microinjection on hippocampal ischemic injury rats.METHODS:Preparation of local cerebral ischemic reperfusion injury model: cortical stereostaxic approach, microinjection of BDNF antibody. Applied immunohistochemical method to observe distribution of BDNF in cortex after injection of the antibody,to observe the alteration of ischemic injury between control group and BDNF antibody group.RESULT: The volume of cerebral infarction in BDNF antibody group was larger than control group.CONCLUSION: BDNF has protection function for cerebral ischemia. 关键词
brain-derived neurotrophic factor/cerebral ischemia/microinjectionsKey words
brain-derived neurotrophic factor/cerebral ischemia/microinjections分类
医药卫生引用本文复制引用
陈英辉,王根发,陈兴华,姚革,陈伟,周永炜..脑源性神经营养因子抗体对大脑中动脉阻塞大鼠缺血损伤的影响[J].中国临床康复,2003,7(1):135-135,1.
