中国临床康复2004，Vol.8Issue(7)：1356-1357,2.
镁离子对脑损伤患者脑功能的保护作用
Neuroprotective effect of magnesium on patients with brain trauma
周国胜 1马秀强 1周文科1
作者信息
- 1. 新乡医学院第一附属医院神经外科,河南省卫辉市,453100
- 折叠
摘要
Abstract
BACKGROUND:It has been proved by animal experiments in recent years that magnesium ion(Mg2+ ) is neuroprotective and has less side effects,but previous trials were not involved in patients with brain trauma. OBJECTIVE:To investigate the efficiency of large dose of magnesium sulfate used in the treatment of brain trauma. DESIGN:Randomized controlled trial was performed and prospective analysis was used. SETTING and PARTICIPANTS:The trial was performed in Xinxiang Medical College between January and June 2001,and all participants were recruited from Neurosurgery Nepartment of the First Affiliated Hospital.According to the standards,43 patients with brain trauma were chosen and assigned to experimental group and control group at random. INTERVENTIONS:Twenty-two patients in experimental group received 16 mmol magnesium sulfate intravenously over 15 minutes as soon as possible after admission and followed by 65 mmol over 24 hours.Twenty-one patients in control group not received magnesium sulfate. MAIN OUTCOME MEASURES:Serum neuron specific enolase(NSE),Glasgow coma score(GCS) and Glasgow outcome score(GOS) of all patients were measured after 3 days,3 weeks and 3 months respectively and the data were analyzed statistically. RESULTS:The serum NSE, GCS and GOS of the experimental group were(21.9± 17.2) μ g/L,12.5± 3.1 and 3.8± 1.7 respectively, while the serum NSE, GCS and GOS of the control group were(42.7± 21.4) μ g/L,10.2± 2.9 and 3.2± 1.5 respectively.Between 2 groups the differences of serum NSE and GCS were significant statistically(t=3.51,P< 0.01 and t=2.52,P< 0.05,respectively),while the difference of GOS was not significant(P >0.05). CONCLUSION:Large dose of magnesium sulfate is effective in treatment of patients with trauma at least within a short term.关键词
脑损伤/功能恢复/硫酸镁/磷酸丙酮酸水合酶分类
医药卫生引用本文复制引用
周国胜,马秀强,周文科..镁离子对脑损伤患者脑功能的保护作用[J].中国临床康复,2004,8(7):1356-1357,2.
