中华医学杂志（英文版）Issue(9)：1359-1363,5.
Expression of multidrug resistance-related markers in primary neuroblastoma
Expression of multidrug resistance-related markers in primary neuroblastoma
摘要
Abstract
Background Multidrug resistance is associated with a poor prognosis in various human cancers. However, the clinical significance of the expression of multidrug resistance-related markers in neuroblastoma is still on debate. In this study, the effect of the expression of p-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), and lung resistance protein (LRP) in neuroblastoma was evaluated. Methods The streptavidin-biotin immunoperoxidase (SP) technique was used to evaluate the expression of P-gp, MRP, and LRP in 70 cases of untreated primary neuroblastoma. Results The frequencies of the expression of P-gp, MRP, and LRP were 61.4%, 38.6%, and 24.3%, respectively. A significant positive correlation was observed between P-gp and MRP expression (P=0.001), as well as between LRP and MRP expression (P=0.01). The rates of expression of P-gp and MRP were higher in tumors from patients aged greater than one year old than in tumors from patients aged less than 1 year old at time of diagnosis (P=0.01 and 0.018, respectively). MRP expression in tumors that had metastasized was significantly more frequent than in tumors that had not metastasized (P=0.015). The expression of all tested proteins showed a significant relationship with whether or not the tumor had differentiated (P=0.006, 0.000 or 0.001, respectively). MRP expression was significantly associated with a reduction in both median survival time and 2-year cumulative survival (P=0.02). By contrast, P-gp and MRP expression did not correlate with survival. According to Cox regression analysis, only the co-expression of P-gp and MRP had significant prognostic value (relative hazard, 3.513, P=0.033). Conclusions The intrinsic, multidrug resistance of neuroblastoma involves the combined effects of P-gp, MRP, and LRP. MRP expression may be an important factor determining prognosis in neuroblastoma.关键词
neuroblastoma/multidrug resistance/p-glycoprotein/multidrug resistance-associated protein/lung resistance proteinKey words
neuroblastoma/multidrug resistance/p-glycoprotein/multidrug resistance-associated protein/lung resistance protein分类
医药卫生引用本文复制引用
吕庆杰,董芳,张锦华,李晓晗,马颖,姜卫国..Expression of multidrug resistance-related markers in primary neuroblastoma[J].中华医学杂志（英文版）,2004,(9):1359-1363,5.基金项目
This study was supported by the National Natural Science Foundation of China (No.39470739). （No.39470739）
