中华医学杂志（英文版）2002，Vol.115Issue(9)：1363-1366,4.
外分泌细胞在Mn-DPDP增强MRI胰腺强化中的作用
Role of exocrine cells in pancreatic enhancement using Mn-DPDP-enhanced MR imaging
龚静山 1徐坚民 1周康荣 2沈坤堂3
作者信息
- 1. 深圳市人民医院,暨南大学医学院第二附属医院,放射科,深圳,518020
- 2. 复旦大学附属中山医院放射科,上海,200032
- 3. 复旦大学附属中山医院普外科,上海,200032
- 折叠
摘要
Abstract
Objective To investigate role of exocrine cells in the pancreatic enhancement images at Manganese (Ⅱ) N,N'-dipyridoxylethlenediamine-N,N'-diacetate 5,5'-bisc (Mn-DPDP)-enhanced magnetic resonance (MR) imaging.Methods Artificial pancreatic leakage was constructed in six dogs using a fistula tube inserted into the duodenum papillae. Pancreatic juice was collected before and after intravenous infusion of 2 ml/kg of Mn-DPDP at a rate of 2-3 ml/min. The Mn content of pancreatic juice was measured by atomic absorption spectroscopy. T1-weighted spin-echo images and T1-weighted spoiled phase gradient-echo (SPGR) images were obtained prior and approximately 30 min after the administration of Mn-DPDP at 1.5T. Results The Mn content of pancreatic secretion increased 60.47±21.83 μg/dl after the administration of Mn-DPDP (t=6.785, P<0.01). The signal/noise ratio (S/N) of the pancreas increased 53%±49% and 62%±44% on T1W spin echo images and SPGR images, respectively.Conclusions Exocrine cells of the pancreas can absorb manganese and excrete it through the pancreatic juice. Exocrine cells play an important role in the enhancement of the pancreas in MR imaging with Mn-DPDP.关键词
胰腺 磁共振成像 对比剂 Mn-DPDPKey words
contrast media/pancreas/magnetic resonance/manganese分类
医药卫生引用本文复制引用
龚静山,徐坚民,周康荣,沈坤堂..外分泌细胞在Mn-DPDP增强MRI胰腺强化中的作用[J].中华医学杂志（英文版）,2002,115(9):1363-1366,4.
