中国药理学与毒理学杂志2001，Vol.15Issue(2)：137-140,4.
1-(2,6-二甲基苯氧基)-2-（3，4-二甲氧基苯乙氨基）丙烷盐酸盐对小鼠脑缺血再灌损伤的保护作用
Protective effects of 1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxy-phenylethylamino) propane hydrochloride on brain ischemia and reperfusion injury in mice
王维亭 1郭莲军 1曲玲 1王芳 1吕青 1钱家庆1
作者信息
- 1. 华中科技大学同济医学院药理学教研室, 湖北武汉 430030
- 折叠
摘要
Abstract
By using decapitating, intravenous injection of saturated MgCl2 and legation of bilateral carotid arteries with vagi, the effects of 1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethyl- amino) propane hydrochloride(DDPH) on survival time in mice were studied. With the model of cerebral ischemia for 20 min and reperfusion for 10 min, effects of DDPH on the superoxide dismutases(SOD) activity and malondialdehyde (MDA) content in brain tissue and pathological changes were studied. The results indicated that DDPH at dosages of 3,6,12,24 mg*kg-1 ip 30 min before ischemia prolonged the survival time significantly. Meanwhile, DDPH was found to increase the activity of SOD and reduce the content of MDA, as well as mitigate pathological damage of neuron after cerebral ischemia and reperfusion in mice. The results suggest that DDPH has protective effects on brain ischemia.关键词
1-(2,6-二甲基苯氧基)-2-（3,4-二甲氧基苯乙氨基）丙烷盐酸盐/脑缺血/再灌注损伤/超氧化物歧化酶/丙二醛分类
医药卫生引用本文复制引用
王维亭,郭莲军,曲玲,王芳,吕青,钱家庆..1-(2,6-二甲基苯氧基)-2-（3，4-二甲氧基苯乙氨基）丙烷盐酸盐对小鼠脑缺血再灌损伤的保护作用[J].中国药理学与毒理学杂志,2001,15(2):137-140,4.
