中国临床康复2004，Vol.8Issue(7)：1382-1383,2.
电针对局灶性脑缺血大鼠神经细胞凋亡及神经生长因子的影响
Influence of electroacupuncture on apoptosis and nerve growth factor of focal cerebral ischemia of rats
骆仲达 1骆仲逵 2许能贵 3赖新生 3尹利华1
作者信息
- 1. 深圳市福田中医院康复中心,广东省深圳市,518034
- 2. 深圳市罗湖区人民医院,广东省深圳市,510802
- 3. 广州中医药大学针灸推拿学院,广东省广州市,510405
- 折叠
摘要
Abstract
AIM:To study the influence of electroacupuncture for dazhui(GV 14) and baihui(GV 20) on apoptosis and nerve growth factor(NGF) of cerebral ischemic rats so as to provide the theoretical basis for acupuncture in the clinical treatment of ischemic cerebrovascular disease. METHODS:Totally 24 healthy male Wistar rats were randomized into pseudo-operation group,ischemia group,and ischemia+ electroacupuncture group,with 8 in each,according to numerical method.Their one side middle cerebral arteries were obstructed and observed with TUNEL staining and immunohistochemical S-P staining. RESULTS:In the ischemia and ischemia+ electroacupuncture groups,the cells of apoptosis 676± 12 and 326± 15 respectively in every 1 000 neurocytes.In the ischemia+ electroacupuncture group,the number of TUNEL positive cells in the infarction area of cerebral cortex were obviously less than that of the ischemia group(P< 0.01). In the ischemia+ electroacupuncture group,the quantity and intensity of NGFR immune positive expression were clearly increased than those in the other two groups (P< 0.01). CONCLUSION:Electroacupuncture functions to inhibit apoptosis,strengthen NGFR expression,and protect the cerebral tissue in ischemia. 关键词
脑缺血/针灸疗法/电针/脱噬作用/体,神经生长因子分类
医药卫生引用本文复制引用
骆仲达,骆仲逵,许能贵,赖新生,尹利华..电针对局灶性脑缺血大鼠神经细胞凋亡及神经生长因子的影响[J].中国临床康复,2004,8(7):1382-1383,2.
