中华医学杂志（英文版）2003，Vol.116Issue(9)：1386-1390,5.
Comparison of remifentanil and fentanyl in patients undergoing modified radical mastectomy or total hysterectomy
Comparison of remifentanil and fentanyl in patients undergoing modified radical mastectomy or total hysterectomy
郭向阳 1易杰 1叶铁虎 1罗爱伦 1黄宇光 1任洪智1
作者信息
- 1. Department of Anesthesiology,Peking Union Medical College Hospital, Beijing 100730, China
- 折叠
摘要
Abstract
Objective To compare the efficacy and safety of remifentanil and fentanyl in patients undergoing a modified radical mastectomy or total hysterectomy.Methods Fifty-four patients were evenly randomised into remifentanil group and fentanyl group. Anesthesia was induced by propofol (1-2 mg/kg) and either remifentanil (2 μg/kg) or fentanyl (2.5 μg/kg), and was maintained with inhalation of nitrous oxide in oxygen (2∶1) and continuous infusion of either remifentanil (0.2 μg*kg-1*min-1) or fentanyl(0.03 μg*kg-1*min-1). Results The number of patients exhibiting light anesthesia responses in the remifentanil group during intubation and the maintenance of anesthesia was significantly less than that in the fentanyl group. Both systolic and diastolic blood pressures in the fentanyl group were significantly higher than those in the remifentanil group during intubation, skin incision, maintenance of anesthesia and extubation. The time to opening eyes on command and the time for extubation after surgery was comparable between the two groups. More patients in the remifentanil group (25 patients) required bolus injection of morphine for postoperative pain relief than those in the fentanyl group (5 patients, P<0.05). There was no significant difference between the two groups in terms of side effects.Conclusions Under the condition of this study protocol, the anesthetic and analgesic effects of remifentanil are more potent than those of fentanyl. Remifentanil can offer superior intraoperative hemodynamic stability in comparison with fentanyl, and has no compromising recovery from anesthesia.关键词
remifentanil/fentanyl/anesthesia/radical mastectomy/total hyscrectomyKey words
remifentanil/fentanyl/anesthesia/radical mastectomy/total hyscrectomy分类
医药卫生引用本文复制引用
郭向阳,易杰,叶铁虎,罗爱伦,黄宇光,任洪智..Comparison of remifentanil and fentanyl in patients undergoing modified radical mastectomy or total hysterectomy[J].中华医学杂志（英文版）,2003,116(9):1386-1390,5.
