中国全科医学2009，Vol.12Issue(15)：1387-1389,3.
8-异前列腺素F2α与阻塞性睡眠呼吸暂停低通气综合征及其合并高血压的相关性研究
Correlation between Plasma 8-Iso-Prostaglandin F2α Level and Obstructive Sleep Apnea-Hypopnea Syndrome Its Complicated Hypertension
摘要
Abstract
Objective To investigate the changes of plasma 8-iso-prostaglandin F 2α(8-iso-PGF2α)in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS)and in those with complicated hypertension(OSAHS+HT),pathophysiological changes of OSAHS,the pathogenesis of OSAHS+HT.Methods Nineteen OSAHS patients (OSAHS group),21 OSAHS patients with complicated hypertension (OSAHS+HT group) and concurrently 20 health persons (control group) were enrolled.The plasma 8-iso-PGF2α in all the subjects were measured by ELISA and the results were compared among the 3 groups.Results The plasma 8-iso-PGF F2αconcentrations were (7.5±2.1)ng/ml in the control group,(11.1±3.3)ng/ml in OSAHS group and (14.8±3.4)ng/ml in OSAHS+HT group.There was a significant difference among the 3 groups (F=30.992,P＜0.01),and there was a significant difference between OSAHS,OSAHS+HT groups and control group(P＜0.01).The correlation analysis showed that the plasma level of 8-iso-PGF2α in OSAHS and OSAHS+HT groups were significantly correlated with the sleep apnea hypopnea index,percentage of SaO2<90% lasting time over the total sleeping time,ratio of sleep apnea time to total sleep time,lowest SaO2 during sleep apnea,average lowest SaO2,and longest time at apnea event (P<0.05).Conclusion Oxidative stress in OSAHS patients goes up,which may be one of the pathogeneses of OSAHS and its complicated hypertension.The plasma OSAHS 8-iso-PGF F2αis obviously correlated with the indices reflecting the severity of sleep apnea.关键词
阻塞性睡眠呼吸暂停低通气综合征/高血压/8-异前列腺素F2α/氧化应激Key words
Obstructive sleep apnea-hypopnea syndrome/Hypertension/8-iso-PGF2α/Oxidative stress分类
医药卫生引用本文复制引用
李萍,平芬,韩书芝,牛占丛,苏力..8-异前列腺素F2α与阻塞性睡眠呼吸暂停低通气综合征及其合并高血压的相关性研究[J].中国全科医学,2009,12(15):1387-1389,3.基金项目
河北省卫生厅科研基金(07161) （07161）
