畜牧兽医学报2001，Vol.32Issue(2)：139-145,7.
表达马立克氏病病毒CVI988／Rispens株糖蛋白B基因的重组鸡痘病毒疫苗的免疫保护研究
PROTECTION STUDIES OF A RECOMBINANT FOWLPOX VIRUS VACCINE EXPRESSING GLYCOPROTEIN B GENE FROM CVI988／RISPENS STRAIN OF MAREK’S DISEASE VIRUS
彭大新 1刘秀梵 1吴长新 1吴艳涛 1文其乙 1高崧 1张如宽 1吴晓丰 1邢力 1朱爱华 1詹爱军1
作者信息
摘要
Abstract
Recombinant fowlpox Virus （rFPV） was constructed to express glycoprotein B （gB） gene from CVI988／Rispens strain of Marek’s disease virus （MDV）．The rFPV－gB／R alone and in combination with herpesvirus of turkey （HVT） preparations were evaluated for their protective efficacy against challenge with different MDV strains in different chickens．The rFPV－gB／R alone induced protection comparable to that by HVT vaccines in both Ab-SPF chickens and Ab＋ production chickens．Significant protective synergism was observed in one of the two commercial production chickens when rFPV－gB／R was combined with HVT of either cell associated or cell free preparations．Immunogenesis studies showed that rFPV－gB／R，just like conventional vaccines，significantly reduced the level of viremia and feather follicle shedding with virus in vaccinated chickens．关键词
重组鸡痘病毒/糖蛋白B基因/马立克氏病毒/CVI988／Rispens株/保护研究分类
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彭大新,刘秀梵,吴长新,吴艳涛,文其乙,高崧,张如宽,吴晓丰,邢力,朱爱华,詹爱军..表达马立克氏病病毒CVI988／Rispens株糖蛋白B基因的重组鸡痘病毒疫苗的免疫保护研究[J].畜牧兽医学报,2001,32(2):139-145,7.
