国际眼科杂志2009，Vol.9Issue(1)：1-4,4.DOI:10.3969/j.issn.1672-5123.2009.01.001
柚皮素对大鼠眼血流和脉络膜新生血管的作用
Effects of naringenin on ocular blood flow and choroidal neovascularization in experimental animals
吉洁 1徐新荣 1邱春亿2
作者信息
- 1. 210029 中国江苏省南京市,江苏省中医院眼科
- 2. 美国德克萨斯农工大学医学院眼科药理研究所
- 折叠
摘要
Abstract
AIM: To investigate the effects of naringenin on laser-induced experimental choroidal neovascularization (CNV) in rat models,ocular blood flow in rabbit eyes and retinal function recovery after ischemic insults in rat eyes.membrane. Naringenin 10g/L(20mg/kg) was given once-daily through intraperitoneal injection for 4 weeks after laser treatment. The development of CNV was determined by fluorescein angiography(FA) performed on weeks 2 and 4. The colored microsphere technique and electroretinography method were used for the study of ocular blood flow and retinal function recovery,respectively.RESULTS: The choroidal blood flow in elevated intraocular pressure (IOP) rabbit eyes was significantly increased by 10g/L naringenin solution as compared to control group(P<0.05) . The retinal function recovery after ischemic insults in rat eyes indicated significant increase of b-wave recovery in treated group,as compared to control group(P<0.05).The intensity of fluorescein leakage from the photocoagulated lesions decreased significantly in treated group,compared to the control group(75.8%-95.0%,P<0.01). CONCLUSION: Naringenin could prevent the development of CNV on laser-induced experimental rat models,increase the choroidal blood flow in elevated IOP rabbit eyes and be beneficial on retinal function recovery in ischemic rat eyes.关键词
柚皮素/脉络膜新生血管/眼血流/年龄相关性黄斑变性Key words
naringenin/choroidal neovascularization/ocular blood flow/age-related macular degeneration分类
医药卫生引用本文复制引用
吉洁,徐新荣,邱春亿..柚皮素对大鼠眼血流和脉络膜新生血管的作用[J].国际眼科杂志,2009,9(1):1-4,4.
