西安医科大学学报2001，Vol.22Issue(1)：1-4,4.
硒、VE对高脂血症家兔血管活性物质的影响
Effects of selenium and vitamin E on vascular activities in hyperlipemia rabbits
摘要
Abstract
Objective To investigate the effects on vascular activities inatherosclerositic rabbits induced by hyperlipemia,and the mechanism of anti-atherosclerositic effects of VE and Se were discussed.Methods Forty domestic male rabbits were divided into 5 groups,and then were fed normal diet or high cholesterol diet,high cholesterol diet with VE,high cholesterol diet with selenium,high cholesterol diet with VE and selenium.In the end of the eighth week,we assayed TC,NO,ET-1,TXA2 and PGI2 in the rabbit bloods.Results ①Hyperlipemia decreased the blood NO level,and increased blood ET-1 level as well as the ratio of TXA2/PGI2 in rabbits;②The antioxidants,VE and Se,could increase the blood NO level and decrease the ratio of TXA2/PGI2 in hyperlipemia rabbits;③Combining effects of VE and Se had stronger effects than single one.Conclusion The results suggest that the mechanisms of anti-atherosclerositic effects of VE and Se might be related to the protections of endothelium and its function.关键词
高脂血症/血管活性物质/维生素E分类
医药卫生引用本文复制引用
康新勤,徐仓宝,龚敏,张亚平,王亚文,于林,权萍..硒、VE对高脂血症家兔血管活性物质的影响[J].西安医科大学学报,2001,22(1):1-4,4.基金项目
陕西省自然科学基金资助课题 （）
