中国人兽共患病杂志2005，Vol.21Issue(1)：1-4,英文目录,5.
日本血吸虫SIEA26-28kDa的抗雌虫生殖免疫作用--HGPRT是否是主要的靶抗原
Anti-fecundity immunity induced by sIEA 26-28kDa antigens of Schistosoma japonicum:is HGPRT antigen a major target for the immunity?
摘要
Abstract
To study the anti-fecundity effect of SIEA26-28kDa antigens from Schistosoma japonicum, the soluble immature egg antigen (SIEA) and the SIEA26-28kDa components from the early-embryo stages eggs were purified through an AcA column and used to immunize BALB/c mice. The mice divided into three groups were immunized with SIEA, SIEA26-28kDa and immunoadjuvant respectively followed by a schistosome challege infection. The worm burden, the differential count of eggs in the host tissues and the schistosomal uterus were performed 46 days after the infection. The result showed that the decrease rates of intrauterine eggs of the female worms were 54.8% after immunization with SIEA26-28kDa, with a statistical difference being highly significant comparing with the control group. The numbers of schistosome eggs in the animal liver and intestine tissues decreased by 48.07% and 77.41%, respectively. To a more remarkable extent, the numbers of the mature eggs in the liver and intestine dropped by 83.6% and 93.3%, respectively, but most remarkably, the fecal egg decrease rate went up to 87.26%. No similar results were observed in the controls. In conclusion, SIEA26-28kDa can be regarded as acandidate antigen used for the induction of anti-embryonation and anti-fecundity immunity.关键词
Schistosoma japonicum/immature egg antigens/anti-fecundity immunityKey words
Schistosoma japonicum/immature egg antigens/anti-fecundity immunity分类
医药卫生引用本文复制引用
李文凯,汪世平,吕志跃,彭先楚,徐绍锐,何卓,周松华,肖小芹,曾少华,戴橄,余俊龙,车宏丽..日本血吸虫SIEA26-28kDa的抗雌虫生殖免疫作用--HGPRT是否是主要的靶抗原[J].中国人兽共患病杂志,2005,21(1):1-4,英文目录,5.基金项目
国家"十·五"重大科技专项课题(No.2002AA2Z3343) （No.2002AA2Z3343）
863国家血防重大专项(No.2004AA2Z3530) （No.2004AA2Z3530）
教育部"985"行动计划专项资金、湖南省"十*五"重点学科建设专项经费(No.2001-2007)联合资助 （No.2001-2007）
