中华医学杂志（英文版）2002，Vol.115Issue(9)：1401-1404,4.
βig-h3在圆锥角膜和正常角膜中的表达
Expression of βig-h3 in keratoconus and normal cornea
赵桂秋 1王传富 1孙为荣 1张文卿 1李艳 1生晖 1梁涛1
作者信息
- 1. 青岛医学院附属医院眼科,青岛,266003
- 折叠
摘要
Abstract
Objectives To observe the expression of βig-h3 in normal cornea and keratoconus and to elucidate the role of extracellular matrix in keratoconus. Methods In situ hybridization was used to detect the expression of βig-h3 in the cornea. The cDNA library was screened with human βig-h3 cDNA probe to locate βig-h3 mRNA in cells. Results Expression of βig-h3 was found mainly in the stroma of the normal cornea and keratoconus, but decrease depending on the degree of keratopathy. In some serious cases, no expression signal was detected. The strongest expression was seen at the border of the normal region and keratoconus. Conclusions βig-h3,the structural component of the extracellular matrix, can affect cell adhensiveness in the development of corneal fibrous interstitial organization. During the development of keratoconus, decreasing levels of βig-h3 cause the diminution of corneal steadiness, which is related to formation of keratoconus.关键词
βig-h3 圆锥角膜 人类 原位杂交 mRNAKey words
βig-h3/keratoconus/in situ hybridization/human/mRNA分类
医药卫生引用本文复制引用
赵桂秋,王传富,孙为荣,张文卿,李艳,生晖,梁涛..βig-h3在圆锥角膜和正常角膜中的表达[J].中华医学杂志（英文版）,2002,115(9):1401-1404,4.
