中华医学杂志（英文版）2008，Vol.121Issue(15)：1407-1410,4.
Association of CALCA genetic polymorphism with essential hypertension
Association of CALCA genetic polymorphism with essential hypertension
摘要
Abstract
Background Calcitonin gene-related peptide (CGRP) is the predominant neurotransmitter in capsaicin-sensitive sensory nerves. Participation of CGRP in hypertension is one of the most extensively studied topics in the field. There is growing evidence to the effect that CGRP is associated with essential hypertension (EH). The aims of this study were to pinpoint whether single nucleotide polymorphisms (SNPs) in the genes coding for CALCA were associated with EH susceptibility in a Hunan Han population.Methods Atotal of 293 subjects with EH and 208 controls were enrolled in the study. Genomic DNA was extracted from peripheral blood leucocytes by a phenol-chloroform method. The CALCA T-692C was genotyped using a restriction fragment length polymorphism method.Results A statistically significant difference in CALCA T-692C genotypic distribution was observed between cases and controls (P=0.001). Moreover, the frequencies of the C allele were 14.85% in the EH group and 7.45% in the control group, prevalence of C alleles in EH subjects and controls was significantly incomparable (P <0.001). Furthermore, the results of Logistic regression analysis showed that the carriers of C allele (TC+CC genotypes) were associated with increased EH risk (OR=2.093, 95% CI: 1.317-3.326, P<0.01).Conclusions CALCA genetic polymorphism is associated with EH susceptibility. Carriers of at least one C allele at the polymorphic site CALCA T-692C showed increased risk for EH.关键词
hypertension/calcitonin gene-related peptide/single nucleotide polymorphismKey words
hypertension/calcitonin gene-related peptide/single nucleotide polymorphism分类
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LUO Xin-lin,YANG Tian-lun,CHEN Xiao-ping,LI Yuan-jian..Association of CALCA genetic polymorphism with essential hypertension[J].中华医学杂志（英文版）,2008,121(15):1407-1410,4.基金项目
This study was supported by a grant from the Scientific Research Foundation of Hunan Department of Public Health (No. B2004-039). （No. B2004-039）
