中国现代医学杂志2007，Vol.17Issue(12)：1409-1412,1417,5.
PTEN和P53蛋白在子宫内膜癌组织中的表达及临床意义
Expression of PTEN and P53 protein in endometrial carcinoma: correlation with clinicopathological features
摘要
Abstract
[Objective] To evaluate the significance of PTEN and mutant P53 expression and the correlations with carcinogenesis and tumor progression in endometrial carcinoma. [Methods] The expression of PTEN and P53 was detected in 40 cases of sporadic endometrial carcinoma and 23 cases of normal endometrium by immunohistochemistry staining. The relationships between the expression of PTEN and P53 and the clinicopathological factors were also examined. [Results] All the normal endometriums showed positive staining of PTEN. While in endometrial carcinoma the expression of PTEN protein was significantly decreased with the positive rate of 52.5%. There were no relationships between the PTEN expression and the clinicopathological factors, including tumor differentiation, clinical stage, histopathological classification, invasion of myometrium and lymphoid metastasis status. The positive rate of P53 protein expression was 17.5% in endometrial carcinomas. No positive staining was detected in normal endometriums. The expression of P53 was associated with histological grade in endometrial carcinomas. Moreover, there was correlation between PTEN and'P53 expression in endometrial carcinomas. [Conclusions] Our study show that PTEN protein expression reduced significantly in endometrial carcinoma and that P53 is overexpressed and associated with histological grade. Our findings suggest that loss of PTEN expression and mutation of P53 play an important role in carcinogenesis and tumor progression in endometrial carcinoma.关键词
子宫内膜肿瘤/抑癌基因/PTEN/P53Key words
endometrial carcinoma/tumor suppressor gene/PTEN/P53分类
医药卫生引用本文复制引用
赵岩,杨清,张淑兰..PTEN和P53蛋白在子宫内膜癌组织中的表达及临床意义[J].中国现代医学杂志,2007,17(12):1409-1412,1417,5.基金项目
Supported by funds from Youth Fund of Liaoning Province Education Committee(No.:05L549) （No.:05L549）
