中国防痨杂志2001，Vol.23Issue(3)：141-147,7.
北京结核菌株分子流行病学的研究
The molecular epidemiology of Mycobacterium tuberculosis in Beijing
张立兴 1丁北川 2邢青 1安燕生1
作者信息
- 1. 北京结核病控制研究所
- 2. 北京结核病控制研究所；本课题为北京市政府重点学科资助项目、国际防痨和肺部疾病联合会IUATLD和英国国家医学研究院National Institute for Medical Research合作研究项目
- 折叠
摘要
Abstract
Objective Typing of Mycobacterium tuberculosis strains and epidemiological studies in Beijing.Methods (1)To detect and analyze the restriction fragment length polymorphism (RFLP) of M.tuberculosis isolated from 128 new patients with pulmonary tuberculosis by using standardized method.(2)A sociodemographical and epidemiological questionnaire investigated all patients selected in this study.(3)The relationship of genotype of M.tuberculosis and their epidemiology were analyzed.Results (1)128 M.tuberculosis detected were belonged in 3 groups, according to their homology of IS6110 fingerprinting.The strains in A and B groups were called as “Beijing genotype strains" because these strains had high homology, and they had a high percentage (103/128,80.5%) in all strains detected.Strains in group C, called as “non-Beijing genotype strains",had lower homology and only 19.5% in all strains detected.(2)The polymorphism of the strains isolated from the younger patients (＜40) were different significantly compared with the strains isolated from those elder patients (＞40).The selectivity predominance of “Beijing genotype" was not due to BCG vaccine widely.(3)The polymorphism of the strains detected were not correlated significantly to past TB contracted history of the patients investigated,living in urban or rural area of Beijing and the drug-resistance of the strains.Conclusion Fingerprinting analysis of M.tuberculosis can be a useful tool for the study of modern epidemiology of tuberculosis.关键词
分支杆菌,结核/DNA指纹/结核/流行病学/北京分类
医药卫生引用本文复制引用
张立兴,丁北川,邢青,安燕生..北京结核菌株分子流行病学的研究[J].中国防痨杂志,2001,23(3):141-147,7.
