中国临床药学杂志2001，Vol.10Issue(1)：14-17,4.
盐酸格拉司琼胶囊的人体药物动力学和相对生物利用度
Pharmacokinetics and relative bioavailability of granisetron hydrochloride capsules in healthy volunteers
李铜铃 1庞怡诺 1陈泽莲 1王志霄 1贾玉蓉 1程强2
作者信息
- 1. 华西医科大学药学院临床药学教研室 成都 610041
- 2. 四川抗菌素研究所药理室 成都 610051
- 折叠
摘要
Abstract
AIM: To study the pharmacokinetics and relative bioavailabilityof granisetron hydrochloride capsules and tablets in healthy volunteers. METHODS: The granisetron hydrochloride concentration in serum was determined by high performance liquid chromatography (HPLC) method after a single oral dose (12 mg) of capsule or tablet was administered to 12 healthy male volunteers respectively in an open randomized cross-over test. RESULTS: After being processed by 3P87 pharmacokinetic program, the experiment data showed that the pharmacokinetic parameters of the capsules and the tablets were AUC0→t: (133.7±61.8) and (131.1±57.4) (ng.h)/ml；AUC0→∞: (150.9±69.8) and (150.6±67.5) (ng.h)/ml；tmax: (2.9±0.4) and (2.9±0.3) h；cmax: (24.6±9.3) and (24.6±0.7) ng/ml respectively. There were no significant differences between AUC and cmax of these 2 preparations (P＞0.05). The relative bioavailability of granisetron hydrochloride capsules was F0→t: (101.5±11.2)% and F0→∞: (100.2±13.5)%. CONCLUSION: These 2 preparations are bioequivalent.关键词
盐酸格拉司琼/相对生物利用度/药物动力学Key words
granisetron hydrochloride/relativebioavailability/pharmacokinetics分类
医药卫生引用本文复制引用
李铜铃,庞怡诺,陈泽莲,王志霄,贾玉蓉,程强..盐酸格拉司琼胶囊的人体药物动力学和相对生物利用度[J].中国临床药学杂志,2001,10(1):14-17,4.
