中华医学杂志（英文版）2003，Vol.116Issue(1)：142-144,3.
Efficacy of recombinant tissue-type plasminogen activator thrombolysis and primary coronary stenting after acute myocardial infarction
Efficacy of recombinant tissue-type plasminogen activator thrombolysis and primary coronary stenting after acute myocardial infarction
陈步星 1王伟民 2赵红 2胡大一 2徐成斌 2赵明中 2卢明瑜 2刘健 2吴淳2
作者信息
- 1. Department of Cardiology, Beijing Electric Power General Hospital, Beijing 100073, China
- 2. Department of Cardiology, People's Hospital, Peking University, Beijing 100044, China
- 折叠
摘要
Abstract
Objective To compare the efficacy of low dose recombinant tissue-type plasminogen activator (rt-PA) thrombolysis with primary coronary stenting after acute myocardial infarction.Methods Of 261 patients with first acute myocardial infarction, 131 were given low dose rt-PA intravenous thrombolysis, and 130 primary coronary stenting.Results The age, time from onset of chest pain to hospital presentation and infarct location between these two groups were comparable. The patency rate of the infarct-related artery (IRA) in patients in the thrombolysis group was significantly lower than that of patients in the primary stenting group (P<0.001). Recurrent myocardial infarction, and selective coronary stenting of patients with thrombolytic therapy were higher than that of patients in the primary stenting group (7.6% vs 1.5%, P<0.05; 20.6% vs 0, P<0.001, respectively). Left ventricular ejection fraction (LVEF) in patients in the thrombolysis group was lower than that of the stent group (55.6%±13.4% vs 65.8%±9.2%, P<0.001). Total hospitalization time of the thrombolysis group was longer than that of the stent group (16±7 d vs 11±4 d, P<0.001). Mortality in the thrombolysis group was higher than that of the stent group, but this difference was not significant (6.1% vs 3.1%, P>0.05).Conclusion Comparing with low dose rt-PA thrombolytic therapy after acute myocardial infarction, primary coronary stenting has a higher patency rate of the IRA, better cardiac function and shorter hospitalization time.关键词
myocardial infarction/therapeutic thrombolysis/plasminogen activatorKey words
myocardial infarction/therapeutic thrombolysis/plasminogen activator分类
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陈步星,王伟民,赵红,胡大一,徐成斌,赵明中,卢明瑜,刘健,吴淳..Efficacy of recombinant tissue-type plasminogen activator thrombolysis and primary coronary stenting after acute myocardial infarction[J].中华医学杂志（英文版）,2003,116(1):142-144,3.
