中国癌症防治杂志2009，Vol.1Issue(2)：142-144,147,4.
5-FU经颞浅动脉120小时持续灌注治疗高T分期鼻咽癌的Ⅰ期临床试验
Phase I clinical trial of nasopharyngeal carcinoma at high T stage treated with 5-FU continued infusion for 120 hours through superficial temporal artery
任培蓉 1吴敬波 1何丽佳 1吴天革 1张建文 1尚昌玲1
作者信息
- 1. 646000,四川泸州,泸州医学院附属医院肿瘤科
- 折叠
摘要
Abstract
Objective To determine the maximum tolerated dose of 5-Flouruorail (5-FU) via superficial temporal arterial infusion for the patients with T3/T4 nasopharyngeal carcinoma.Methods A total of 29 patients were enrolled in this study.They were treated with 5-FU plus Cisplatin.A chemotherapy cycle was designed as 21 days and all patients were treated for 2 cycles.5-FU was administrated by pump infusion for continuous 120-hour via superficial temporal arterial.The maximum tolerated dose of 5-FU was determined by testing increasing doses on different groups of patient until the highest dose with acceptable side effects was found.Cisplatin was infused via superficial temporal artery (20mg/m2/d,d1-5) for all the patients.Results 5-FU induced oral mucositis in all patients.Of the 29 patients,1 patient experienced grade I mucositis in group 200mg/m2; 12 patients experienced grade II mucositis which included 5 in group 200mg/m2,5 in group 300mg/m2 and 2 in group 350mg/ m2; 11 patients experienced grade III mucositis which included 1 in group 300mg/m2,3 in group 350mg/m2,5 in group 400mg/m2 and 2 in group 450mg/m2; 5 patients experienced grade IV mucositis which included 3 in group 450mg/m2 and 2 in group 500mg/m2.Five patients experienced oral mucosal pain.For the primary tumor,2 cases achieved complete remission (CR),25 achieved partial remission (PR) and 2 presented stable disease (SD),in which the overall response rate (CR+PR) was 93%.For the neck lymph nodes,the cases of CR,PR and SD were 1,16 and 0 respectively,the rest 12 were neck-node-negative,in which the CR+PR was 100%.Conclusion s Superficial temporal arterial infusion with 5-FU for T3/T4 nasopharyngeal carcinoma is well tolerated.The maximum tolerated dose of 5-FU is 350mg/m2.关键词
鼻咽癌/5-FU/动脉化疗/最大耐受剂量Key words
Nasopharyngeal carcinoma/5-fluorouracil/Intra-arterial chemotherapy/ Maximum tolerated dose分类
医药卫生引用本文复制引用
任培蓉,吴敬波,何丽佳,吴天革,张建文,尚昌玲..5-FU经颞浅动脉120小时持续灌注治疗高T分期鼻咽癌的Ⅰ期临床试验[J].中国癌症防治杂志,2009,1(2):142-144,147,4.
