中国药理学通报2001，Vol.17Issue(2)：142-146,5.
RU486对硫酸皮质酮引起的头端延髓腹外侧区心血管神经元作用的影响
The responses of RU486 to the effects of corticosterone sulfate on
cardiovascular neurons in the rostral ventrolateral medulla of rats
王伟忠 1汪雪梅 2戎伟芳 1王继江 1袁文俊1
作者信息
- 1. 第二军医大学生理学教研室,
- 2. 安徽省卫生职工培训中心,
- 折叠
摘要
Abstract
AIM To study the roles of non-genomi c mechanism of glucocorticoid in the integration of sympathetic nervous system. METHODS The spontaneous discharge of the identified cardiovascula r neurons in the rostral ventrolateral medulla (RVLM) were extracellularly recor ded in urethane-anaesthetized rats. The effects of microiontophoresis of cortic ostersone sulfate (CORT) on the discharge of the cardiovascular neurons in the RVLM were observed. The responses of RU 486 (a blocker for cytosolic glucocortic oids) to the effects of CORT on the cardiovascular neurons were investigated. RESULTS Totally 33 cardiovascular neurons in the RVLM were recorded , the firing rate of 25 (76%) cardiovascular neurons increased by microiontophor esis of CORT. The effects of CORT were also positively correlated with the curre nt. In 8 (24%) cardiovascular neurons, microiontophoresis of CORT had no effect on their spontaneous discharge. In 12 of 33 cardiovascular neurons, which discha rge increased by CORT, microiontophoresis of RU 486 had no responses to the base line discharge of these cardiovascular neurons (P>0.05), but completely (3 neurons) or partially (9 neurons) blocked the excitatory effect induced by CORT. CONCLUSION CORT had rapid excitatory effects on the cardiovascul ar neurons in the RVLM. RU 486 had no responses to the baseline activity of the cardiovascular neurons, and but completely or partially blocked the effect of CO RT on the cardiovascular neurons.关键词
RU486/硫酸皮质酮/心血管神经元/微电泳/细胞外记录分类
医药卫生引用本文复制引用
王伟忠,汪雪梅,戎伟芳,王继江,袁文俊..RU486对硫酸皮质酮引起的头端延髓腹外侧区心血管神经元作用的影响[J].中国药理学通报,2001,17(2):142-146,5.
