中国全科医学2009，Vol.12Issue(15)：1426-1427,2.
卡培他滨化疗同步放射治疗局部晚期直肠癌的疗效观察
Capecitabine Chemotherapy Concurrent with Radiotherapy for Patients with Locally Advanced Rectal Cancer
吾甫尔·艾克木 1王若峥 1王多明1
作者信息
- 1. 830011,新疆乌鲁木齐市,新疆医科大学附属肿瘤医院放疗一科
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of Capecitabine chemotherapy concurrent with radiotherapy in patients with locally advanced rectal cancer.Methods Twenty-two patients with advanced rectal cancer were given Capecitabine (Xeloda) 1 300 mg·m-2·d-1 orally,twice a day,for two continuous weeks,and then with one week rest,which was a course.This was done twice during the period of radiotherapy.Concomitant radiotherapy to the whole pelvic area was external irradiation TD,and total dose of TD was 60-68 Gy/30-35 F.Results After treatment,among the 22 patients,there 3 (13.6%) reached complete response (CR),13 (59.1%) partial response (PR),2 (9.1%) stable disease (SD),and 4 (18.2%) progressed disease (PD),with a total response rate of 72.7%.One-year local control rate was 68.2% (15/22),one-year survival rate was 81.8% (18/22),and 2-year survival rate was 50% (11/22).The main toxicity were radiation proctitis and bone marrow suppressionConclusion The Capecitabine chemotherapy concurrent with radiotherapy has a better efficacy for locally advanced rectal cancer,and its toxicity is tolerable by the patient.关键词
卡培他滨/放射疗法/直肠肿瘤/治疗结果Key words
Xeloda/Radiotherapy/Rectal neoplasms/Treatment outcome分类
医药卫生引用本文复制引用
吾甫尔·艾克木,王若峥,王多明..卡培他滨化疗同步放射治疗局部晚期直肠癌的疗效观察[J].中国全科医学,2009,12(15):1426-1427,2.
