中华医学杂志（英文版）2009，Vol.122Issue(12)：1435-1438,4.DOI:10.3760/cma.j.issn.0366-6999.2009.12.015
Curcumin inhibits amygdaloid kindled seizures in rats
Curcumin inhibits amygdaloid kindled seizures in rats
摘要
Abstract
Background Curcumin can reduce the severity of seizures induced by kainate acid (KA), but the role of curcumin in amygdaloid kindled models is still unknown. This study aimed to explore the effect of curcumin on the development of kindling in amygdaloid kindled rats.Methods With an amygdaloid kindled Sprague-Dawley (SD) rat model and an electrophysiological method, differentdoses of curcumin (10 mg·kg-1·d-1 and 30 mg·kg-1·d-1as low dose groups, 100 mg·kg-1·d-1 and 300 mg·kg-1·d-1 as high dose groups) were administrated intraperitoneally during the whole kindling days, by comparison with the course of kindling, afterdischarge (AD) thresholds and the number of Ads to reach the stages of class Ⅰ to Ⅴ seizures in the rats between control and experimental groups. One-way or two-way ANOVA and Fisher's least significant difference post hoc test were used for statistical analyses.Results Curcumin (both 100 mg·kg-1·d-1 and 300 mg·kg-1·d-1) significantly inhibited the behavioral seizure development in the (19.80±9.25) and (21.70±9.21) stimulations respectively required to reach the kindled state. Rats treated with 100 mg·kg-1·d-1 curcumin 30 minutes before kindling stimulation showed an obvious increase in the stimulation current intensity required to evoke AD from (703.3±85.9) μA to (960.0±116.5) μA during the progression to class Ⅴ seizures. Rats treated with 300 mg·kg-1·d-1 curcumin showed a significant increase in the stimulation current intensity required to evoke AD from (735.0±65.2) μA to (86±7.093.4) μA during the progression to class Ⅴ seizures. Rats treated with 300 mg·kg-1·d-1 curcumin required much more evoked Ads to reach the stage of class both Ⅳ (as (199.83±12.47) seconds) and Ⅴ seizures (as (210.66±10.68) seconds). Rats treated with 100 mg·kg-1·d-1 curcumin required much more evoked Ads to reach the stage of class V seizures (as (219.56±18.24) seconds). Conclusion Our study suggests that curcumin has a potential antiepiieptogenic effect on kindling-induced epileptogenesis.关键词
curcumin/amygdala/kindling, neurologic/epileptogenesisKey words
curcumin/amygdala/kindling, neurologic/epileptogenesis分类
医药卫生引用本文复制引用
DU Peng,LI Xin,LIN Hao-jie,PENG Wei-feng,LIU Jian-ying,MA Yu,FAN Wei,WANG Xin..Curcumin inhibits amygdaloid kindled seizures in rats[J].中华医学杂志（英文版）,2009,122(12):1435-1438,4.基金项目
This study was supported by grants from National Natural Science Committee (No.30470593), a fund from Institute of Brain Science of Fudan University (2008), and a youth fund from Shanghai Municipal Health Bureau (2009). （No.30470593）
