首页|期刊导航|中华医学杂志（英文版）|Influence of patients' age on functional recovery after transplantation of olfactory ensheathing cells into injured spinal cord injury
中华医学杂志（英文版）2003，Vol.116Issue(10)：1488-1491,4.
Influence of patients' age on functional recovery after transplantation of olfactory ensheathing cells into injured spinal cord injury
Influence of patients' age on functional recovery after transplantation of olfactory ensheathing cells into injured spinal cord injury
摘要
Abstract
Objective To evaluate the restoration of function after spinal cord injury (SCI) in patients of different ages who have underwent intraspinal transplantation of olfactory ensheathing cells (OECs). Methods One hundred and seventy-one SCI patients were included in this study. Of them, 139 were male and 32 were female, with age ranging from 2 to 64 years (mean, 34.9 years). In all SCI patients the lesions were injected at the time of operation with OECs. According to their ages, the patients were divided into 5 groups: ≤20 years group (n=9), 21-30 years group (n=54), 31-40 years group (n=60), 41-50 years group (n=34) and>51 years group (n=14). The spinal cord function was assessed based on the American Spinal Injury Association (ASIA) Classification System before and 2-8 weeks after OECs transplantation. One-way ANOVA and q test were used for statistical analysis, and the data were expressed as mean±SD.Results After surgery, the motor scores increased by 5.2±4.8, 8.6±8.0, 8.3±8.8, 5.7±7.3 and 8.2±7.6 in 5 age groups respectively (F=1.009, P=0.404); light touch scores increased by 13.9±8.1, 15.5±14.3, 12.0±14.4, 14.1±18.5 and 24.8±25.3 respectively (F=1.837, P=0.124); and pin prick scores increased by 11.1±7.9, 17.2±14.3, 13.2±11.8, 13.6±13.9 and 25.4±24.3 respectively (F=2.651, P=0.035). Restoration of pin prick in >51 years group was better than other age groups except 21-30 years group. Conclusion OECs transplantation can improve the neurological function of spinal cord of SCI patients regardless of their ages. Further research into the long-term outcomes of the treatment will be required.关键词
cell transplantation/spinal cord injury/function recoveryKey words
cell transplantation/spinal cord injury/function recovery分类
医药卫生引用本文复制引用
黄红云,陈琳,王洪美,修波,李炳辰,王锐,张健,张峰,顾征,李荧,宋英伦,郝伟,潘树义,孙君昭..Influence of patients' age on functional recovery after transplantation of olfactory ensheathing cells into injured spinal cord injury[J].中华医学杂志（英文版）,2003,116(10):1488-1491,4.基金项目
This study was supported by grants from the Chinese Ministry of Education (No. 2002-247) and the Naval Logistic Department (No. 02-3310). （No. 2002-247）
