安徽农业大学学报2004，Vol.31Issue(1)：1-5,5.
人类1号染色体可变剪接与普通剪接基因同义密码子的使用分析I.同义密码子偏爱使用分析
Synonymous Codon Usage of Both Alternatively and Commonly Spliced Genes in Human Chromosome 1 I:Synonymous Codon Usage Bias Analysis
摘要
Abstract
It is already clear that alternative splicing has an extremely important role in expanding the protein diversity. Comparative study of the codon usage patterns of alternatively and commonly spliced genes may thereby be necessary. In this paper, the patterns of codon usage bias of two kinds of human genes, alternatively spliced genes and commonly spliced genes, were formulated through analyzing 344 non-redundant protein coding sequences from alternatively spliced genes (188183 codons) and 386 from commonly spliced genes (223116 codons) in human chromosome 1. Overall codon usage data analysis indicated that the alternatively spliced genes showed a stronger codon usage bias than commonly spliced genes. Very extensive heterogeneity of G+C content in silent third codon position (GC3s) was evident among these genes, and GC3s content of alternatively spliced genes was higher than that of commonly spliced genes. G- or C-ending codons were more abundant in alternatively spliced genes than commonly spliced genes in human chromosome 1. The causation of differences created could be explained by pre-mRNA structural characteristics of alternatively spliced genes influencing their codon usage bias.关键词
可变剪接/普通剪接/密码子使用/人类Key words
alternative splicing/common splicing/codon usage/human分类
生物科学引用本文复制引用
陈学平,武耀廷,郭家明,张成,马飞..人类1号染色体可变剪接与普通剪接基因同义密码子的使用分析I.同义密码子偏爱使用分析[J].安徽农业大学学报,2004,31(1):1-5,5.基金项目
China postdoctoral programs foundation(200211). （200211）
