中国药理学与毒理学杂志2009，Vol.23Issue(1)：1-5,5.DOI:10.3867/j.issn.1000-3002.2009.01.001
吲达帕胺对大鼠替米沙坦药代动力学的影响及性别差异
Influence of indapamide on pharmacokinetics of telmisartan in male and female rats
王明霞 1单保恩 1李巍巍 1王敏 1苏喜改1
作者信息
- 1. 河北医科大学第四医院,河北,石家庄,050011
- 折叠
摘要
Abstract
AIM To study the influence of indapamide(Ind) on pharmacokinetics of telmisartan(Tel) and observe the difference between male and female rats. METHODS Wistar rats were divided into Tel and Tel+Ind groups, each group containing 8 female and 8 male rats, and were ig administered a single dose of either Tel 3.6 mg·kg-1 or Tel 3.6 mg·kg-1+Ind 0.135 mg·kg-1, respectively. Blood samples were collected at intervals over 96 h after administration. The Tel concentrations in plasma were determined by high performance liquid chromatography with fluorescence detector. The Tel concentration-time curves were simulated by 3p97 software and the pharmacokinetic parameters were calculated. RESULTS Whatever in female or male rats, there were no significant differences in the main pharmacokinetic parameters of Tel between Tel and Tel+Ind groups. However, females had higher values for area under the concentration-time curve and maximum plasma concentration than males, but lower values for total clearance in both Tel and Tel+Ind groups. CONCLUSION Ind has no significant influences on the pharmacokinetics of Tel. However, pharmacokinetics of Tel is significant different between male and female rats.关键词
替米沙坦/吲达帕胺/药代动力学/色谱法,高压液相Key words
telmisartan/indapamide/pharmacokinetics/chromatography, high pressure liquid分类
医药卫生引用本文复制引用
王明霞,单保恩,李巍巍,王敏,苏喜改..吲达帕胺对大鼠替米沙坦药代动力学的影响及性别差异[J].中国药理学与毒理学杂志,2009,23(1):1-5,5.
