中国临床康复2003，Vol.7Issue(10)：1508-1509,2.
实验性内囊出血后脊髓前角缝隙连接对肌痉挛的影响
Effects of gap junction of motoneuron in spinal cord on spasticity following experimental capsular hemorrhage in rats
摘要
Abstract
Aim To investigate the effects on spasticity from motoneuron gap junction (GJ) in rat spasticity model, changes of motor evoked potentials (MEPs) and the express of connexin 32 in anterior horn motoneuron were observed following experimental cerebral hemorrhage.Methods The arterial blood from rat tail artery was slowly injected into the hindlimb of the right capsule, which induced pyramidal tract to damage, and the spastic model of capsular hemiplegia rats was produced.MEPs were recorded from the gastrocnemius muscle, and the connexin32 was observed with immunohistochemical method.Results Following the right capsule - orientated hemorrhage the amplitude of motor evoked potential for the right sensomotor cortex was obviously decreased in contrast with those for the left (P< 0.01), the latencies of MEP for the right sensorimotor cortex were significantly elongated in comparison with those for the left (P< 0.01), moreover, the latencies for the right after 1 week post - hemorrhage were markedly prolonged as compared with prehemorrhage (P< 0.01).At the first week after capsular hemorrhage,the express of connexin 32 in the left anterior horn of spinal cord for the right internal capsule was significantly increased compared with levels for pre - injury (P< 0.05) ,and the degree of the spasticity in rat was elevated.Conclusion Capsule - orientated hemorrhage may induce the amplitude of MEP for the injured side decreased obviously and the latencies of MEP elongated.These show the functional state and injured condition for corticospinal tract to a certain degree, it induces gap junction in anterior horn motoneuron to increase.This may be the important cause for the spasticity production.关键词
脑出血/诱发电位,运动/肌痉挛Key words
cerebral hemorrhage/evoked potential,motor/muscle spasticity分类
医药卫生引用本文复制引用
蒋晓江,李书林,刘娟..实验性内囊出血后脊髓前角缝隙连接对肌痉挛的影响[J].中国临床康复,2003,7(10):1508-1509,2.基金项目
解放军第三军医大学校管课题(2001001) （2001001）
