中华医学杂志（英文版）2007，Vol.120Issue(17)：1511-1516,6.
Effect of smoking cessation on airway inflammation of rats with chronic bronchitis
Effect of smoking cessation on airway inflammation of rats with chronic bronchitis
LI Qing-yun 1HUANG Shao-guang 1WAN Huan-ying 1WU Hua-cheng 2ZHOU Tong 3LI Min 1DENG Wei-wu1
作者信息
- 1. Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
- 2. Department of Pathology ,Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
- 3. Department of Nephrology ,Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
- 折叠
摘要
Abstract
Background Smoking is the major cause of airway inflammation in chronic obstructive pulmonary disease (COPD),and smoking cessation is regarded as one of the important strategies for prevention and treatment of the inflammation.The inflammation of the chronic airway may be present and deteriorated even if the COPD patients stop smoking.Whether and how early smoking cessation affects the progress of inflammation is still obscure. This study was conducted to find the appropriate time for smoking cessation to terminate the airway inflammation in rats with smoke-induced chronic bronchitis.Methods A rat model of COPD was established by passively inhaling smoke mixture. Fifty-four young male Sprague-Dawley rats were randomly divided into 9 groups with different periods of smoke exposure and different time points of cessation. The inflammation markers to be detected included inflammatory cells in the bronchoalveolar lavage fluid (BALF), the myeloperoxidose (MPO) activity, the morphologic changes and the expression of ICAM-1 on the airway epithelium.Results When smoking was terminated at early stage, the inflammatory markers and related indexes were different from those of the typical chronic bronchitis group (group M7) (P＜0.01). The pathologic score of group SC7 (2 weeks of smoking cessation after occurrence of typical chronic bronchitis ) was not different from that of group M7, and the level of ICAM-1 was still up-regulated (compared to group M7, P＞0.05). Meanwhile, most of inflammatory cells in BALF were neutrophils compared to other groups (P＜0.01).When smoking was terminated, the MPO activity was significantly lower than that of group M7 (P＜0.01).Conclusions Smoking cessation at early stage can effectively inhibit the inflammatory reaction of COPD. Once chronic bronchitis occurs, little could be improved by smoking cessation.关键词
smoke/ chronic bronchitis/ inflammation/ smoking cessationKey words
smoke/ chronic bronchitis/ inflammation/ smoking cessation分类
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LI Qing-yun,HUANG Shao-guang,WAN Huan-ying,WU Hua-cheng,ZHOU Tong,LI Min,DENG Wei-wu..Effect of smoking cessation on airway inflammation of rats with chronic bronchitis[J].中华医学杂志（英文版）,2007,120(17):1511-1516,6.
